摘要
目的:研究冻干重组人脑利钠肽治疗老年扩张型心肌病合并心力衰竭的效果及对血清指标的影响。方法:选取2019年6月-2020年6月本院收治的老年扩张型心肌病合并心力衰竭患者90例,按照随机数字表法将其分为研究组和对照组,每组45例。两组患者均进行常规治疗,对照组在此基础上采用曲美他嗪治疗,研究组在对照组基础上采用冻干重组人脑利钠肽治疗。治疗1周后,观察两组患者的临床疗效与安全性,对比治疗前后组间心功能指标、AngⅡ、NT-proBNP等血清指标。结果:研究组总有效率为95.56%,明显高于对照组的80.00%(P<0.05)。研究组、对照组患者的不良反应发生率分别为8.89%、6.67%,组间比较差异无统计学意义(P>0.05)。两组患者治疗前的心功能指标比较,差异均无统计学意义(P>0.05);治疗后,研究组患者的LVEF、LVEDD、LVESD、LVPWT水平均明显优于对照组(P<0.05)。两组患者治疗前的血清指标比较,差异均无统计学意义(P>0.05);治疗后,研究组患者的AngⅡ、NT-proBNP、ET-1、ALD水平均明显低于对照组(P<0.05)。结论:冻干重组人脑利钠肽治疗老年扩张型心肌病合并心力衰竭的效果较好,可有效抑制患者的心室重构,改善血清指标,且安全性较好,值得临床应用。
Objective:To study the effect of Lyophilized Recombinant Human Brain Natriuretic Peptide on senile dilated cardiomyopathy complicated with heart failure and its effect on serum indexes.Method:A total of 90 elderly patients with dilated cardiomyopathy and heart failure in our hospital from June 2019 to June 2020 were selected and randomly divided into study group and control group according to the random number table method,with 45 cases in each group.The control group was treated with Trimetazidine,and the study group was treated with Lyophilized Recombinant Human Brain Natriuretic Peptide.After one week of treatment,the differences of clinical efficacy and safety between the two groups were observed,and the indexes of cardiac function,AngⅡ,NT-proBNP and other serum indexes before and after treatment between the two groups were compared.Result:The total effective rate of the study group was 95.56%,which was significantly higher than 80.00% of the control group (P<0.05).The incidence of adverse reactions in the study group and the control group were 8.89% and 6.67% respectively,and there was no significant difference between the two groups (P>0.05).There were no significant differences in cardiac function indexes between the two groups before treatment (P>0.05);after treatment,the levels of LVEF,LVEDD,LVESD and LVPWT in the study group were significantly better than those in the control group (P<0.05).There were no significant differences in serum indexes between the two groups before treatment (P>0.05);after treatment,the levels of AngⅡ,NT-proBNP,ET-1 and ALD in the study group were significantly lower than those in the control group (P<0.05).Conclusion:The effect of Lyophilized Recombinant Human Brain Natriuretic Peptide in the treatment of elderly patients with dilated cardiomyopathy complicated with heart failure is good,which can effectively inhibit ventricular remodeling,improve serum indicators,and has good safety,so it is worthy of clinical application.
作者
李竹
LI Zhu(Zhuanghe Central Hospital,Zhuanghe 116400,China)
出处
《中国医学创新》
CAS
2021年第29期10-13,共4页
Medical Innovation of China
