摘要
雷公藤红素是源于雷公藤根部的重要活性成分,在促进脂质消耗、控制体质量等方面拥有独特效果,被公认为是最有潜力的减肥药。该文综述雷公藤红素参与机体脂质代谢的国内外相关研究最新进展,从瘦素敏感性、胰岛素抵抗、脂肪细胞分化、线粒体功能、炎性控制以及肠道微生态等方面,系统阐述雷公藤红素调控机体脂质代谢及相关分子生物学机制,为促进基于雷公藤红素代谢药物的研发提供科学参考。
Celastrol,extracted from the root of Tripterygium wilfordii,has been recognized as the most potential anti-obesity drug for its unique effects on the regulation of body mass and lipid metabolism.Based on the latest developments in domestic and foreign research on celastrol,this paper systematically reviews the role of celastrol in the regulation of lipid metabolism and provides a summary of the molecular biological mechanisms involved,such as increasing the sensitivity to leptin receptors sensitivity,inhibiting insulin resistance,increasing energy consumption,suppressing the differentiation of adipocytes,improving intestinal microecology,and anti-inflammatory control,aiming to promote the research and development of metabolic drugs based on celastrol.
作者
周永强
周维
岳兰昕
邓慧芳
邱丽珍
倪毓浩
高月
ZHOU Yongqiang;ZHOU Wei;YUE Lanxin;DENG Huifang;QIU Lizhen;NI Yuhao;GAO Yue(Academy of Military Medical Sciences,Institute of Radiation Medicine,Anti-radiation Drug Research Laboratory,Beijing 100850,China)
出处
《医药导报》
CAS
北大核心
2021年第12期1704-1709,共6页
Herald of Medicine
基金
国家自然科学基金重点资助项目(81630102)
国家自然科学基金青年科学基金资助项目(81803833)。
