摘要
目的:观察参苓白术散加减方联合强的松治疗对原发性肾病综合征患者临床疗效、炎性因子及血液流变学的影响。方法:选择2018年1月~2020年6月与本院接受诊治的87例原发性肾病综合征患者作为研究对象,根据纳入排除标准最终选取82例患者;根据不同诊治方式分为研究组(n=41)和对照组(n=41),对照组患者予以强的松治治疗,研究组予以参苓白术散加减方联合强的松治疗。比较两组患者临床疗效、炎性因子、血液流变学、生存质量及不良反应。结果:(1)研究组总有效率(95.12%)高于对照组(73.17%)(P<0.05);(2)研究组与对照组治疗前炎性因子比较未见明显差异(P>0.05),治疗后,两组患者TNF-a、IL-6、hn-CRP水平较治疗前下降,以研究组为甚(P<0.05)。(3)治疗前,两组血液流变学指标比较未见明显差异(P>0.05),治疗后,两组ESR、HCT、PSV、HSV、LSV水平明显降低,研究组水平较对照组下降明显(P<0.05)。(4)治疗后,两组患者SF-36量表(躯体疼痛、生理职能、生理功能、社会功能、情感职能、精神健康、总体健康、精力)评分较前升高,研究组显著高于对照组(P<0.05)。(5)对照组出现感染、头痛、胃肠道不适等不良反应总发生率明显高于研究组(P<0.05)。结论:参苓白术散加减方联合强的松治疗原发性肾病综合征患者临床疗效显著,可改善炎性因子及血液流变学水平,降低患者不良反应,提升患者生存质量,值得临床推广。
Objective:To analyze the effect of Shenling Baizhu Powder Modified Recipe combined with Prednisone on clinical efficacy,inflammatory factors and hemorheology for patients with primary nephrotic syndrome.Methods:87 patients with primary nephrotic syndrome who were diagnosed and treated in this hospital from January 2018 to June 2020 were selected as the research objects,and 82 patients were finally selected according to the inclusion and exclusion criteria.According to different methods of diagnosis and treatment,they were divided into a study group(n=41)and a controlled group(n=41).Patients in the controlled group were treated with Prednisone,and the study group was treated with Shenling Baizhu Powder Modified Recipe combined with prednisone.The clinical efficacy,inflammatory factors,hemorheology,quality of life and adverse reactions were compared between the two groups.Results:(1)The total effective rate of the study group(95.12%)was higher than that of the controlled group(73.17%)(P<0.05).(2)There was no significant difference in inflammatory factors between the study group and the controlled group before treatment(P>0.05).After treatment,the levels of TNF-a,IL-6,and hn-CRP in the two groups were lower than those before treatment,especially in the study group(P<0.05).(3)Before treatment,there was no significant difference in hemorheological indexes between the two groups(P>0.05).After treatment,the levels of ESR,HCT,PSV,HSV,and LSV in the two groups significantly reduced,and the levels in the study group were significantly lower than those in the controlled group(P<0.05).(4)After treatment,the scores of patients in the two groups on the SF-36 scale(physical pain,physiological function,physiological function,social function,emotional function,mental health,general health,energy)were higher than those before treatment,and the score of the study group was significant higher than that of the controlled group(P<0.05).(5)The total incidence of adverse reactions such as infection,headache and gastrointestinal discomfo
作者
胡娟
HU Juan(Department of Nephrology,Dazhou Hospital of Integrated Traditional Chinese and Western Medicine,Dazhou Sichuan 635000,China)
出处
《四川中医》
2021年第10期117-120,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
原发性肾病综合征
强的松
参苓白术散
影响
Primary nephrotic syndrome
Prednisone
Shenlingbaizhu Powder
Influence
