摘要
目的描述中国东北地区心血管病高危人群特征、危险因素分布及预防用药情况,为制定心血管病精准防控策略提供数据参考。方法以2014—2019年东北地区黑龙江、吉林、辽宁3个省份26个区县中414346名35~75岁的常住居民为研究人群,计算人群整体以及根据年龄、性别、地区、社会经济特征分组后的高危对象检出比例,并应用多元混合模型评价个体特征与心血管病风险之间的关联,同时选择指南推荐的预防用药(他汀类药物和阿司匹林)来评价高危人群中的治疗情况。结果在中国东北地区35~75岁的414346名调查对象中,8.9%为心血管病高危对象,这一比例在男性中和农村地区相对更高。混合模型结果显示,高学历、已婚、有医疗保险的人群更不易患心血管病;高收入(家庭年收入>50000元)人群更倾向于是心血管病高危对象。在高危人群中,报告正在服用他汀类药物和阿司匹林的比例均为0.4%。结论在中国东北地区35~75岁的筛查对象中,接近9%为心血管病高危对象,指南推荐的适宜使用他汀类药物和阿司匹林预防使用率均不足1%。在这一人群中,降低心血管病风险势在必行。
Objective To describe the characteristics of risk factors and the usage of prevention drugs for cardiovascular diseases(CVD) among adult residents in Northeastern China and to provide evidence data for developing strategies on precise prevention and control of cardiovascular diseases. Methods From the dataset of Patient-Centered Evaluative Assessment of Cardiac Events(PEACE) conducted across China from 2014 to 2019, we extracted the data on 414 346 permanent residents aged 35 – 75 years in 26 county-level regions in 3 northeastern provinces of China. The overall and age-,sex-, geographic region-, and socioeconomic status-specific ratio of people at high of CVD risk were calculated for the participants. Multivariate mixed model was adopted to assess associations of individual characteristics with CVD risk factors.The usage of statins and aspirin recommended in China′ s national guidelines for CVD prevention was also analyzed to evaluate CVD preventive medication among the participants at high CVD risk. Results Of all the participants, 8.9% were identified as individuals at high risk of CVD, and the ratio was relatively higher among the male and rural participants. Mixed model analysis revealed that the participants with higher education, being married and with medical insurance were less likely to be at high risk of CVD but those with an annual household income of 50 000 Yuan RMB were more likely to be at high risk of CVD. Of the participants with high CVD risk, only 0.4% reported taking both statins and aspirin currently.Conclusion Among the 35 – 75 years old permanent residents in Northern China, nearly 9% are individuals at high risk of cardiovascular diseases;whereas, less than 1% of the high risk individuals have current medication of statins and aspirin recommended by national guidelines for cardiovascular disease prevention, suggesting that relevant interventions should be promoted among the high risk population for the prevention of the diseases.
作者
杨阳
朱志鸿
张行易
崔建兰
许巍
吴超群
田娜
任晶晶
陈杨
路甲鹏
YANG Yang;ZHU Zhi-hong;ZHANG Xing-yi(National Clinical Research Center of Cardiovascular Diseases,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 102308 China)
出处
《中国公共卫生》
CSCD
北大核心
2021年第10期1483-1488,共6页
Chinese Journal of Public Health
基金
国家科技部国家重点研发计划(2017YFC1310801)
财政部、国家卫生健康委项目。
关键词
东北地区
心血管疾病
高危人群
预防用药
Northeastern China
cardiovascular disease
high risk population
preventive medication
