摘要
目的探讨胸部螺旋CT扫描和肿瘤标志物联合检测结果对于肺癌早期筛查的参考价值。方法方便选取2019年9月—2020年8月期间于该院体检,胸部CT检查考虑恶性待排的111例体检者作为研究对象,先后进行胸部螺旋CT复查和肿瘤标志物检测,结合检查、检测结果进行分析。结果穿刺或手术后病理组织活检检出肺癌57例,良性病变54例。与肺部良性病变患者相比,肺癌患者的癌胚抗原(CEA)水平[(15.97±4.06)ng/mL>(2.81±0.57)ng/mL]、鳞状细胞癌抗原(SCC)水平[(4.18±0.39)ng/mL>(1.45±0.22)ng/mL]、胃泌素释放肽前体(ProGRP)水平[(85.13±4.56)pg/mL>(53.54±6.09)pg/mL]、细胞角蛋白19片段(CYFRA21-1)水平[(5.65±2.06)ng/mL>(1.58±0.47)ng/mL]相对更高,差异有统计学意义(t=23.594、45.084、31.042、14.170,P<0.05)。在体检人群肺癌早期筛查中,胸部螺旋CT扫描和肿瘤标志物联合检测的敏感度、特异度和准确度分别为96.49%、98.15%和97.30%,显著高于胸部螺旋CT扫描(73.68%、79.63%和76.58%)和肿瘤标志物检测(75.44%、77.78%和76.58%),差异有统计学意义(P<0.05)。结论在体检人群肺癌早期筛查中,实施胸部螺旋CT扫描和肿瘤标志物联合检测,在检测结果中,能够真实、准确反映出肺癌的发生情况,与相似症状疾病进行鉴别,便于早期治疗工作的顺利开展。
Objective To explore the reference value of the combined detection results of chest spiral CT scan and tumor markers for the early screening of lung cancer.Methods A total of 111 patients who underwent physical examination in the hospital from September 2019 to August 2020 and who were considered to be malignant in chest CT examination were conveniently selected as the research subjects.The patients underwent chest spiral CT reexamination and tumor marker detection successively,and the results of examination and test were analyzed.Results 57 cases of lung cancer and 54 cases of benign lesions were detected by biopsy after puncture or operation.Compared with patients with benign lung lesions,CEA levels in patients with lung cancer[(15.97±4.06)ng/mL>(2.81±0.57)ng/mL],SCC level[(4.18±0.39)ng/mL>(1.45±0.22)ng/mL,],ProGRP[(85.13±4.56)pg/mL>(53.54±6.09)pg/mL],cytokeratin 19 fragment(CYFRA21-1)levels[(5.65±2.06)ng/mL>(1.58±0.47)ng/mL]were relatively higher,the difference was statistically significant(t=23.594,45.084,31.042,14.170,P<0.05).In the early screening of lung cancer in the physical examination population,the sensitivity,specificity and accuracy of the combined detection of chest spiral CT scan and tumor markers were 96.49%,98.15%and 97.30%,respectively.It was significantly higher than that of spiral CT scan(73.68%,79.63%and 76.58%)and tumor marker detection(75.44%,77.78%and 76.58%),the difference was statistically significant(P<0.05).Conclusion In the early screening of lung cancer in the physical examination population,the combined detection of chest spiral CT scan and tumor markers can truly and accurately reflect the occurrence of lung cancer in the detection results,and distinguish diseases with similar symptoms,which is convenient for the smooth development of early treatment.
作者
魏雯
唐劲松
陈喆
WEI Wen;TANG Jinsong;CHEN Zhe(Physical Examination Center,the Second People's Hospital Affiliated to Fujian University of Chinese Medicine,Fuzhou,Fujian Province,350001China)
出处
《中外医疗》
2021年第26期190-193,共4页
China & Foreign Medical Treatment
基金
福建省科技计划项目(2020Y0043)。
关键词
胸部螺旋CT
肿瘤标志物
联合检测
肺癌早期筛查
Chest spiral CT
Tumor markers
Joint detection
Early screening for lung cancer
