摘要
目的探讨结直肠癌根治术患者术后辅助化疗依从性的影响因素。方法收集130例结直肠癌根治术患者的病历资料,分析患者术后辅助化疗依从性的影响因素。结果客观性影响因素的单因素分析结果显示,不同年龄、性别、术后并发症、体重指数(BMI)、体表面积(BSA)结直肠癌根治术患者术后辅助化疗依从性比较,差异均有统计学意义(P﹤0.05);不同肿瘤位置、病理类型结直肠癌根治术患者术后辅助化疗依从性比较,差异均无统计学意义(P﹥0.05)。进一步行多因素Logistic回归分析,结果显示,年龄≥65岁、女性、术后出现并发症、BMI﹤22 kg/m^(2)、BSA﹤1.6 m^(2)是影响结直肠癌根治术患者术后辅助化疗依从性的客观性独立危险因素(P﹤0.05)。主观性影响因素的单因素分析结果显示,不同对生命的态度、家庭经济情况、病情保密、家庭支持、不良反应结直肠癌根治术患者术后辅助化疗依从性比较,差异均有统计学意义(P﹤0.05);就医困难结直肠癌根治术患者术后辅助化疗依从性比较,差异无统计学意义(P﹥0.05)。进一步行多因素Logistic回归分析,结果显示,对生命绝望、家庭经济困难、不对病情保密、无家庭支持、无法耐受不良反应是影响术后辅助化疗依从性的主观性独立危险因素(P﹤0.05)。接受化疗患者病死率为2.78%(2/72),低于拒绝化疗患者的12.07%(7/58),差异有统计学意义(χ^(2)=4.303,P=0.038)。结论结直肠癌根治术患者术后辅助化疗依从性的主观性及客观性影响因素较多,临床医护人员可根据具体的影响因素采取有效的干预措施,从而提高患者术后辅助化疗治疗依从性,改善患者预后。
Objective To explore the influencing factors of postoperative adjuvant chemotherapy compliance in patients undergoing radical resection of colorectal cancer.Method The clinical data of 130 patients treated with radical colorectal cancer surgery were collected.The influencing factors of postoperative adjuvant chemotherapy compliance were analyzed.Result The results of univariate analysis of the objective independent factors showed that there were significant differences of postoperative adjuvant chemotherapy compliance in patients undergoing radical resection of colorectal cancer with different age,gender,postoperative complications,body mass index(BMI)and body surface area(BSA)(P<0.05).There was no significant difference of postoperative adjuvant chemotherapy compliance in patients undergoing radical resection of colorectal cancer with different tumor location and pathological type after radical resection of colorectal cancer(P>0.05).Multivariate Logistic regression analysis showed that age≥65 years old,female,postoperative complications,BMI<22 kg/m^(2) and BSA<1.6 m^(2) were objective independent risk factors affecting the postoperative adjuvant chemotherapy compliance in patients undergoing radical resection of colorectal cancer.The results of single factor analysis of subjective influencing factors showed that there were significant differences of the postoperative adjuvant chemotherapy compliance in patients undergoing radical resection of colorectal cancer with different attitudes towards life,family economic situation,condition confidentiality,family support and adverse reactions after radical resection of colorectal cancer(P<0.05).There was no significant difference of postoperative adjuvant chemotherapy compliance in patients undergoing radical resection of colorectal cancer(P>0.05).Multivariate Logistic regression analysis showed that life despair,family financial difficulties,no confidentiality of the condition,no family support and intolerance were the subjective independent risk factors of postopera
作者
杨丰华
白献红
王晓珂
刘慧革
贺瑞蕊
任红艳
YANG Fenghua;BAI Xianhong;WANG Xiaoke;LIU Huige;HE Ruirui;REN Hongyan(Department of Phase Ⅰ Clinical Research Center,Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450003,He’nan,China;Department of Nursing,Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450003,He’nan,China;Department of General Surgery,Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450003,He’nan,China;Department of Gastroenterology,Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450003,He’nan,China)
出处
《癌症进展》
2021年第19期2008-2011,共4页
Oncology Progress
关键词
结直肠癌根治术
辅助化疗
依从性
radical resection of colorectal cancer
adjuvant chemotherapy
compliance
