摘要
目的探讨肾病综合征患者选用环磷酰胺冲击治疗的价值。方法方便选取2019年2月—2020年6月该院接收的102例肾病综合征患者作为研究对象,按1∶1比例分为对照组(n=51,选用常规方案治疗)、观察组(n=51,选用环磷酰胺冲击治疗),统计两组临床疗效、不良反应率、临床指标、肾功能。结果观察组临床疗效(96.08%)高于对照组(82.35%),差异有统计学意义(χ^(2)=4.993,P<0.05)。观察组TNF-α(81.12±20.62)ng/L、IL-6(113.72±29.85)ng/L、CRP(5.11±1.16)mg/L低于对照组,差异有统计学意义(t=4.058、2.834、3.731,P<0.05)。观察组BUN(7.85±0.52)mmol/L、24 h尿蛋白(0.62±0.31)g/24 h、UACR(62.45±4.11)mg/g低于对照组,差异有统计学意义(t=17.095、16.592、30.595,P<0.05)。观察组不良反应率(9.80%)与对照组(5.88%)相比,差异无统计学意义(χ^(2)=0.136,P﹥0.05)。结论环磷酰胺在肾病综合征治疗中效果确切,可改善其肾功能、炎症状态,亦可提高治疗有效性,值得借鉴。
Objective To explore the value of cyclophosphamide pulse therapy for patients with nephrotic syndrome.Methods Conveniently selected 102 patients with nephrotic syndrome accepted ty the hospital from February 2019 to June 2020 as the research object,and they were divided into a control group(n=51,using conventional treatment)and an observation group(n=51,using cyclophosphamide shock treatment)at a ratio of 1:1,statistics of clinical efficacy,adverse reaction rate,clinical indicators,renal function of the two groups.Results The clinical efficacy of observation group(96.08%)was higher than that of control group(82.35%),and the difference was statistically significant(χ^(2)=4.993,P<0.05).TNF-α(81.12±20.62)ng/L,IL-6(113.72±29.85)ng/L and CRP(5.11±1.16)mg/L in the observation group were lower than those in the control group,and the differences were statistically significant(t=4.058,2.834,3.731,P<0.05).BUN(7.85±0.52)mmol/L,24 h urinary protein(0.62±0.31)g/24 h and UACR(62.45±4.11)mg/g in the observation group were lower than those in the control group,the differences were statistically significant(t=17.095,16.592,30.595,P<0.05).There was no significant difference in the adverse reaction rate between the observation group(9.80%)and the control group(5.88%)(χ^(2)=0.136,P>0.05).Conclusion Cyclophosphamide has a definite effect in the treatment of nephrotic syndrome.It can improve its renal function and inflammation,and can also improve the effectiveness of treatment.It is worth learning.
作者
吴大琴
WU Daqin(Department of Nephrology,Traditional Chinese Medicine Hospital of Xinghua City,Xinghua,Jiangsu Province,225700 China)
出处
《中外医疗》
2021年第25期95-97,104,共4页
China & Foreign Medical Treatment
关键词
环磷酰胺
肾病综合征
安全性
有效性
肾功能
不良反应
Cyclophosphamide
Nephrotic syndrome
Safety
Effectiveness
Renal function
Adverse reactions
