摘要
目的:系统评价中医外治法治疗阻塞性睡眠呼吸暂停综合征(Obstructive Sleep Apnea Syndrome,OSAS)的临床疗效。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库(CBM)等数据库,收集建库至2020年7月中医外治法治疗OSAS的随机对照试验,由2位研究员独立进行文献筛选、提取数据、评价质量并交叉核对结果,采用RevMan 5.3软件进行Meta分析。结果:共纳入23篇随机对照试验文献,Cochrane偏倚风险为高风险,文献均未报道与外治法相关的严重不良反应。Meta分析结果显示,中医外治法能够改善患者的睡眠呼吸暂停低通气指数[MD=-7.33,95%CI(-9.05,-5.56)]、提高夜间最低氧饱和度[MD=3.91,95%CI(1.46,6.37)],改善Epworth嗜睡量表评分[MD=-2.63,95%CI(-3.50,-1.76)]及中医证候积分[MD=-2.57,95%CI(-4.21,-0.93)]效果优于对照组(P <0.05)。结论:中医外治法可在一定程度上改善患者临床症状,且易于被患者接受。
Objective:To evaluate the clinical effect of TCM external treatment on obstructive sleep apnea syndrome.Methods:The databases such as CNKI,WANFANG,VIP and CBM were searched by computer to collect the randomized controlled trial of external treatment of OSAS from database construction period to July 2020.Literature screening,data extraction,quality evaluation and crosschecking were carried out independently by two researchers,and the RevMan 5.3 software was used for Meta-analysis.Results:There were 23 randomized controlled trial articles with a high risk of Cochrane bias.None of which reported serious adverse reactions associated with external therapy.The results of Meta-analysis showed that external treatment of TCM could improve sleep [MD=-7.33,95%CI(-9.05,-5.56)],increasing lowest oxygen saturation at night [MD=3.91,95% CI(1.46,6.37)],improved ESS score [MD=-2.63,95%CI(-3.50,-1.76)] and TCM Syndrome score [MD=-2.57,95%CI(-4.21,-0.93)],the effect better than control group(P<0.05).Conclusion:External treatment of TCM can improve the symptoms of nocturnal sleep apnea and daytime sleepiness to a certain extent.The operation is simple,well tolerated and easy to be accepted by patients.
出处
《中医临床研究》
2021年第22期130-135,共6页
Clinical Journal Of Chinese Medicine
基金
广东省中医院科学技术研究专项(YN2019ML11、YN2019QJ13)
广州中医药历史文化基地项目(L202002)
广东省中医药健康服务与产业发展研究中心项目(2020YJZX012)。