摘要
目的探讨针刺治疗痰浊闭阻证稳定型心绞痛患者的临床效果及对血清脂蛋白相关磷脂酶A2(Lp-PLA2)水平的影响。方法选取2018年10月至2020年6月沈阳医学院附属第二医院心内科收治的116例痰浊闭阻证稳定型心绞痛患者作为研究对象,采用随机数字表法将其分为西药对照组和针刺治疗组,每组各58例。西药对照组予扩张冠状动脉、抗血小板聚集及降脂稳定斑块等常规西药治疗,针刺治疗组在西药对照组基础上联合针刺治疗,两组均连续治疗12周。比较两组中医证候积分、西雅图心绞痛调查量表评分、心电图运动平板试验与血清血脂、Lp-PLA2水平变化情况。结果针刺治疗组中医证候临床有效率高于西药对照组(P <0.05);治疗后两组西雅图心绞痛调查量表评分与心电图运动平板试验指标均较治疗前显著升高(P <0.05),中医证候积分与血清三酰甘油(TAG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、Lp-PLA2水平均较治疗前显著降低(P <0.05)。与西药对照组比较,治疗后针刺治疗组西雅图心绞痛调查量表评分与心电图运动平板试验指标均显著升高(P <0.05),中医证候积分与血清TAG、TC、LDL-C、Lp-PLA2水平均显著降低(P <0.05)。结论针刺治疗痰浊闭阻证稳定型心绞痛患者临床效果显著,可有效改善临床症状,提高生活质量与心功能,降低血脂与血清Lp-PLA2水平。
Objective To investigate the clinical effect of acupuncture on patients with stable angina pectoris with syndrome of blockade of phlegm-turbidity and its effect on serum lipoprotein-associated phospholipase A2(Lp-PLA2)level.Methods A total of 116 patients with stable angina pectoris with syndrome of blockade of phlegm-turbidity admitted to the Department of Cardiology,the Second Affiliated Hospital of Shenyang Medical College from October 2018 to June 2020 were selected as the research objects.They were divided into Western medicine control group and acupuncture treatment group by random number table method,with 58 patients in each group.The Western medicine control group was treated with conventional Western medicine such as coronary artery dilation,anti-platelet aggregation and reducing lipid to stabilize plaque,while the acupuncture treatment group was treated with acupuncture on the basis of the Western medicine control group.Both groups received continuous treatment for 12 weeks.The changes of traditional Chinese medicine syndrome score,Seattle angina questionnaire score,electrocardiogram treadmill exercise test,serum lipid and Lp-PLA2 levels were compared between the two groups.Results The clinical effective rate of traditional Chinese medicine syndrome in acupuncture treatment group was higher than that in Western medicine control group(P < 0.05).After treatment,Seattle angina questionnaire score and electrocardiogram treadmill exercise test index were significantly higher than before treatment(P < 0.05).Traditional Chinese medicine syndrome score and serum levels of triacylglycerol(TAG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C) and Lp-PLA2 were significantly decreased compared with those before treatment(P < 0.05).Compared with the Western control group,theSeattle angina questionnaire score and electrocardiogram treadmill exercise test index in the acupuncture treatment group after treatment were significantly increased(P < 0.05),and the traditional Chinese medicine syndrome score a
作者
孙艳
李博慧
王泽林
SUN Yan;LI Bohui;WANG Zelin(Department of Cardiology,the Second Affiliated Hospital of Shenyang Medical College,Liaoning Province,Shenyang110002,China;Department of Outpatient,Shijingshan Retreat for Retired Cadres in Beijing Garrison Area,Beijing100007,China;Department of Rehabilitation,Beijing Jinkang Traditional Chinese Medicine Hospital,Beijing102488,China)
出处
《中国医药导报》
CAS
2021年第29期68-72,共5页
China Medical Herald
基金
国家“十二五”科技支撑计划项目(2014BAI10B00)。
关键词
稳定型心绞痛
针刺治疗
痰浊闭阻证
脂蛋白相关磷脂酶A2
Stable angina pectoris
Acupuncture therapy
Syndrome of blockade of phlegm-turbidity
Lipoprotein-associated phospholipase A2
