摘要
脊髓损伤(SCI)是脊髓在外部因素的作用下完整性遭到破坏而出现机体以下的运动、感觉和自主神经功能暂时或永久的丧失。外泌体是细胞自身分泌的一种直径40~100 nm的细胞外囊泡,能够作为运输载体参与免疫反应中的细胞间信号转导,有效减少脊髓神经细胞损伤。目前免疫细胞以及外泌体在SCI中的具体作用和对后续炎症影响的机制仍不明确。本文旨在探索SCI后免疫细胞与外泌体的神经免疫调控的机制及新的治疗靶点以及改善预后的新方案。
Spinal cord injury(SCI)is a temporary or permanent loss of motor,sensory and autonomic nerve functions below the body due to the destruction of the integrity of the spinal cord under the action of external factors.Exosomes are extracellular vesicles with a diameter of 40 to 100 nm secreted by cells themselves.They can be used as transport carriers to participate in intercellular signal transduction in immune response and effectively reduce spinal cord nerve cell injury.At present,the specific role of immune cells and exosomes in SCI and the mechanism of their effect on subsequent inflammation remain unclear.The purpose of this review is to explore the mechanism of neuro-immune regulation of immune cells and exosomes after SCI,as well as new therapeutic targets and new schemes for improved healing.
作者
丁华
张磊
袁即山
樊晓臣
姚翔
吕斌
Hua Ding;Lei Zhang;Jishan Yuan;Xiaochen Fan;Xiang Yao;Bin Lyu(Department of Orthopaedics,The Affiliated People’s Hospital of Jiangsu University,Zhenjiang 212002,China;Department of Orthopaedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《中华神经创伤外科电子杂志》
2021年第5期305-309,共5页
Chinese Journal Of Neurotraumatic Surgery：Electronic Edition
基金
江苏省卫生健康委员会医学科研项目(Z2020003、Z20200058)
镇江市重点研发计划(社会发展)项目(SH2019085)
江苏大学临床医学科技发展基金(JLY2021010、JLY2021012)
江苏大学研究生创新计划项目(SJCX21-1725)。
关键词
脊髓损伤
外泌体
神经免疫
Spinal cord injury
Exosomes
Neuro-immune
