摘要
目的探讨超声瞬时弹性成像(UTE)技术与MSCT灌注成像对慢性乙型肝炎(CHB)肝纤维化的诊断价值。方法选取2019年10月至2020年6月间收治的68例CHB肝纤维化患者(观察组)作为研究对象,并纳入同期30例体检健康者作为对照组。所有研究对象均行UTE和MSCT灌注成像检查,记录研究对象肝脏弹性值(LSM)、肝动脉灌注量(ALP)、门脉灌注量(PVP)、肝脏灌注指数(HPI)、血流量(BF)、血容量(BV)和渗透性(P)。评估两组不同参数的差异,评估不同参数诊断肝纤维化、肝硬化的效能。结果(1)观察组LSM、HPI均高于对照组(P<0.05),观察组PVP、BF、BV均低于对照组(P<0.05),两组P、ALP对比差异无统计学意义(P>0.05);(2)CHB肝纤维化患者各纤维化分期LSM、PVP、HPI、BF、BV对比差异均有统计学意义(P<0.05),ALP、P对比差异均无统计学意义(P>0.05);(3)ROC曲线显示:LSM、HPI、PVP、BF、BV诊断CHB肝纤维化的曲线下面积分别为0.924、0.662、0.873、0.926、0.957(P<0.05);(4)ROC曲线显示:各参数诊断纤维化分期≥S2曲线下面积最高者是BV,各参数诊断纤维化分期≥S3曲线下面积最高者是HPI,各参数诊断纤维化分期S4曲线下面积最高者是BF。结论UTE与MSCT灌注成像诊断CHB肝纤维化均效能良好,且各有优势。
Objective To explore the diagnostic value of ultrasound transient elastography(UTE)and MSCT perfusion imaging on chronic hepatitis B(CHB)hepatic fibrosis.Methods 68 patients with CHB hepatic fibrosis(observation group)admitted between October 2019 and June 2020 were enrolled as the study subjects,and another 30 healthy examiners at the same time period were included in the control group.UTE and MSCT perfusion imaging were performed in all subjects,and the liver stiffness measurement(LSM),hepatic artery perfusion(ALP),portal vein perfusion(PVP),hepatic perfusion index(HPI),blood flow(BF),blood volume(BV)and permeability(P)were recorded among study subjects.The differences of parameters were evaluated in the two groups,and the efficacy of different parameters in diagnosing hepatic fibrosis and hepatic cirrhosis was evaluated.Results The LSM and HPI in the observation group were higher than those in the control group(P<0.05)while the PVP,BF,and BV in the observation group were lower than those in the control group(P<0.05),and there were no significant differences in the P and ALP between the two groups(P>0.05).There were significant differences in the LSM,PVP,HPI,BF,and BV among the patients with CHB hepatic fibrosis in each fibrosis stage(P<0.05),and there were no significant differences in the ALP and P(P>0.05).ROC curve showed that the values of area under the curve of LSM,HPI,PVP,BF,and BV in the diagnosis of CHB hepatic fibrosis were 0.924,0.662,0.873,0.926,and 0.957,respectively(P<0.05).ROC curve showed that the area under the curve was the highest in BV in the diagnosis of fibrosis stage≥S2,and the area under the curve was the highest in HPI in the diagnosis of fibrosis stage≥S3,and the area under the curve was the highest in BF in the diagnosis of fibrosis stage S4.Conclusion Both UTE and MSCT perfusion imaging have good efficacy in diagnosing CHB hepatic fibrosis,and each has its advantages.
作者
任卫华
李新
雷一鸣
折文利
REN Wei-hua;LI Xin;LEI Yi-ming;SHE Wen-li(Ultrasound Diagnosis and Treatment Center,Xi'an International Medical Center Hospital,Xi'an 710100,Shaanxi Province,China;Department of Ultrasound Medicine,Tongchuan People's Hospital,Tongchuan 727000,Shaanxi Province,China)
出处
《中国CT和MRI杂志》
2021年第12期99-102,共4页
Chinese Journal of CT and MRI
