摘要
A convenient synthetic route to 2-heteroaryl-3-hydroxybenzo[b]thiophene derivatives via K_(2)CO_(3)-promoted multicomponent cycliza-tion between o-halogenated benzaldehyde,2-methylquinolines and sulfur powder has been demonstrated.This reaction is performed smoothly under simple conditions to give the corresponding products in moderate to good yields.The resultant 3-hydroxybenzo[b]thiophenes have been proved to be versatile building blocks in a range of transition-metal-catalyzed cross-coupling reactions.
基金
supported by the National Natural Science Foundation of China(Nos.21871226,21502160,21572194)
the Scientific Research Fund of Hunan Provincial Education Department(19B564)
the Hunan Provincial Natural Science Foundation of China(No.2020JJ3032)
the China Postdoctoral Science Foundation(Nos.2018M632976 and 2019T120709)
the Scientific Research Fund of Xiangtan University(No.XDCX2020B110)
the Open Fund of Guangdong Provincial Key Laboratory of Lumines-cence from Molecular Aggregates,Guangzhou,510640,China(South China University of Technology,No.2019B030301003).
