摘要
目的观察喘可治注射液联合高流量呼吸湿化治疗仪(AIRVO_(2))治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭的临床效果及对患者炎症介质、细胞免疫状态的影响。方法选取东莞市中医院呼吸与危重症医学科2019年9月至2020年11月住院的122例AECOPD合并呼吸衰竭患者,采用随机数字表方法分为治疗组及对照组,各61例,两组各脱漏1例,完成60例。对照组依照指南给予AIRVO_(2)、抗感染、化痰平喘常规治疗;治疗组在对照组的基础上加用喘可治注射液肌内注射,疗程均为14 d。观察两组治疗前后的中医证候积分,外周血白细胞总数(WBC)、C反应蛋白(CRP)、动脉血pH值、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、外周血白介素1β(IL-1β)、白介素8(IL-8)、T淋巴细胞亚群分析(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))。结果治疗前两组的中医证候积分、WBC、CRP、pH值、PaO_(2)、PaCO_(2)、IL-1β、IL-8以及外周血T淋巴细胞亚群分析指标比较,差异无统计学意义(P>0.05)。治疗后两组的WBC、CRP、PaCO_(2)、IL-1β、IL-8、CD8^(+)指标低于治疗前,差异有统计学意义(P<0.05);治疗后两组的pH值、PaO_(2)、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)指标高于治疗前,差异有统计学意义(P<0.05)。治疗组治疗后的WBC、CRP、PaCO_(2)、IL-1β、IL-8、CD8^(+)指标低于对照组,差异有统计学意义(P<0.05);治疗组治疗后的pH值、PaO_(2)、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)指标高于对照组,差异有统计学意义(P<0.05)。结论喘可治注射液联合AIRVO_(2)治疗能显著改善AECOPD合并呼吸衰竭的临床效果,改善患者的炎症反应及细胞免疫状态。
Objective To observe the clinical effect of Chuankezhi injection combined with high flow humidified oxygen delivery devices(AIRVO_(2))in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with respiratory failure and its influence on inflammatory mediators and cellular immune status.Methods A total of 122 AECOPD patients with respiratory failure admitted to the Department of Pulmonary and Critical Care Medicine of Dongguan Hospital of Traditional Chinese Medicine from September 2019 to November 2020 were selected and divided into the treatment group and the control group according to random number table method,61 cases in each group,1 case left out in each group,and 60 cases completed in each group.The control group was given AIRVO_(2),anti infection,expectorant and bronchial relaxation according to the guidelines.The treatment group was given Chuankezhi Injection on the basis of the control group.And the course of treatment was 14 days in each group.The traditional Chinese medicine syndrome score,the total white blood cell(WBC)count,C-reactive protein(CRP),arterial blood pH value,arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))and peripheral blood interleukin-1β(IL-1β),analysis of interleukin-8(IL-8)and T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))were observed before and after treatment between the two groups.Results There were no significant difference in the traditional Chinese medicine syndrome score,the levels of WBC,CRP,pH value,PaO_(2),PaCO_(2),IL-1β,IL-8 and T lymphocyte subsets before treatment between the two group(P>0.05).After treatment,the levels of WBC,CRP,PaCO_(2),IL-1β,IL-8 and CD8^(+)in the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the levels of pH value,PaO_(2),CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the two groups were higher than those before treatment,and the differences were statistically significant(P
作者
钱旭胜
李碧芳
陶海澜
朱碧媛
连乐燊
王应康
郭伟星
QIAN Xu-sheng;LI Bi-fang;TAO Hai-lan;ZHU Bi-yuan;LIAN Le-shen;WANG Ying-kang;GUO Wei-xing(Department of Pulmonary and Critical Care Medicine,Dongguan Hospital of Traditional Chinese Medicine,Guangdong Province,Dongguan 523000,China)
出处
《中国当代医药》
CAS
2021年第31期168-172,共5页
China Modern Medicine
基金
广东省东莞市社会科技发展一般项目(201950715002619)。
关键词
喘可治注射液
高流量呼吸湿化治疗仪
慢性阻塞性肺疾病
呼吸衰竭
细胞免疫
Chuankezhi injection
High flow humidified oxygen delivery devices
Chronic obstructive pulmonary disease
Respiratory failure
Cellular immunity
