摘要
目的探讨2型糖尿病(T2DM)患者血清Nesfatin-1、热休克蛋白60(HSP60)与下肢血管病变(LEVD)的相关性。方法选取120例T2DM患者,根据下肢血管超声检查是否合并LEVD分为两组,LEVD组62例,非LEVD组58例,另选取50名体检健康者为对照组,测定所有研究对象血清Nesfatin-1、HSP60水平,分析血清Nesfatin-1、HSP60水平与T2DM患者合并LEVD的关系。结果LEVD组血清Nesfatin-1水平明显低于非LEVD组,HSP60水平明显高于非LEVD组(P<0.05);不同LEVD分级患者血清Nesfatin-1水平随着病变分级的增加而降低,HSP60水平随着病变分级的增加而升高(P<0.05);Pearson相关性分析显示,体质指数(BMI)、腰臀比(WHR)、糖化血红蛋白(HbA1c)、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、低密度脂蛋白胆固醇(LDLC)、谷丙转氨酶(ALT)、血清肌酐(SCr)、血尿素氮(BUN)水平与Nesfatin-1水平呈负相关,与HSP60水平呈正相关;高密度脂蛋白胆固醇(HDLC)水平与Nesfatin-1水平呈正相关,与HSP60水平呈负相关(P<0.05);多因素逐步Logistic回归分析显示,Nesfatin-1、HSP60为T2DM患者合并LEVD独立影响因素(P<0.05)。结论T2DM合并LEVD患者血清Nesfatin-1水平明显降低,HSP60水平明显升高,且随着病变严重程度而变化,为LEVD独立影响因素,及早检测血清Nesfatin-1、HSP60水平有助于及时防治LEVD。
Aim To investigate the correlation between serum Nesfatin-1,heat shock protein 60(HSP60)and lower extremity vascular disease(LEVD)in patients with type 2 diabetes(T2DM).Methods A total of 120 T2DM patients were selected and divided into two groups according to whether the lower extremity vascular ultrasound examination was combined with LEVD,62 cases in the LEVD group,58 cases in the non-LEVD group,and the other fifty healthy subjects were selected as the control group,the serum Nesfatin-1 and HSP60 levels of all subjects were measured,and the relationship between serum Nesfatin-1,HSP60 levels and LEVD in T2DM patients was analyzed.Results The serum Nesfatin-1 level was significantly lower in the LEVD group than that in the non-LEVD group,and the HSP60 level was significantly higher than that in the non-LEVD group(P<0.05);the serum Nesfatin-1 level in patients with different LEVD grades decreased with the increase of the disease grade,and the HSP60 level increased with the increase of lesion grade(P<0.05);Pearson correlation analysis showed that body mass index(BMI),waist to hip ratio(WHR),glycosylated hemoglobin(HbA1c),fasting blood glucose(FPG),fasting insulin(FINS),insulin resistance index(HOMA-IR),low-density lipoprotein cholesterol(LDLC),alanine aminotransferase(ALT),serum creatinine(SCr),blood urea nitrogen(BUN)levels were negatively correlated with Nesfatin-1 level,and positively correlated with HSP60 levels;high-density lipoprotein cholesterol(HDLC)levels were positively correlated with Nesfatin-1 level,and negatively correlated with HSP60 level(P<0.05);multivariate stepwise Logistic regression analysis showed that Nesfatin-1,HSP60 was independent influencing factors of T2DM patients with LEVD(P<0.05).Conclusions Serum Nesfatin-1 level in T2DM patients combined with LEVD were significantly reduced,and HSP60 levels were significantly increased,and changed with the se-verity of the disease.They are independent factors affecting LEVD.Early detection of serum Nesfatin-1 and HSP60 lev-els can help prevent LEVD
作者
刘莉芳
赵桁
张云良
李宝新
王翯
辛欢欢
董越华
杨颖
LIU Lifang;ZHAO Heng;ZHANG Yunliang;LI Baoxin;WANG He;XIN Huanhuan;DONG Yuehua;YANG Ying(Department of Endocrinology,Baoding First Central Hospital of Hebei Province,Baoding,Hebei 071000,China;Department of Ultrasonography,Baoding First Central Hospital of Hebei Province,Baoding,Hebei 071000,China)
出处
《中国动脉硬化杂志》
CAS
2021年第11期965-970,共6页
Chinese Journal of Arteriosclerosis
基金
保定市科技计划项目(1951ZF060)。
