摘要
目的比较单中心公民逝世后器官捐献与活体器官捐献肾移植临床效果。方法选择2017年1月1日至2018年12月31日于安徽医科大学第一附属医院完成肾移植且随访资料完整的254例肾移植受者为研究对象,并根据供肾类型将其分为活体器官捐献组(n=113)和公民逝世后器官捐献组(n=141)。收集两组受者性别、年龄、身高、术前体质量、术前及术后第3天、第7天、术后1个月、术后2个月、术后12个月血清肌酐和术后住院时间;观察肾移植术后两组受者急性排斥反应、移植物功能延迟恢复(DGF)及肺部感染等并发症发生情况以及受者/移植肾存活情况。正态分布计量资料采用独立样本t检验进行比较。非正态分布计量资料采用Mann-Whitney U检验进行比较。计数资料采用卡方检验或Fisher确切概率法进行比较。采用Kaplan-Meier法绘制公民逝世后器官捐献组和活体器官捐献组受者术后生存曲线并采用log-rank检验进行比较。P<0.05为差异有统计学意义。结果活体器官捐献组受者年龄、术前透析时间、术后住院时间以及术后第3天、第7天、1个月和2个月血清肌酐分别为(32±8)岁、48(42,56)个月、21(22,25)d以及(195±121)、(135±73)、(113±53)和(115±49)μmol/L,公民逝世后器官捐献组分别为(42±10)岁、8(15,25)个月、23(30,45)d以及(483±326)、(333±267)、(208±160)和(172±138)μmol/L,差异均有统计学意义(t=8.552、-7.844、-7.055、-6.129和-2.139,Z=-7.002和-2.810,P均<0.05)。公民逝世后器官捐献组和活体器官捐献组受者围手术期DGF、术后肺部感染和急性排斥反应发生率分别为29.1%(41/141)和4.4%(5/113)、23.4%(33/141)和3.5%(4/113)、14.9%(21/141)和8.0%(9/113),差异均有统计学意义(χ^(2)=25.707、19.889和4.637,P均<0.05)。随访至2020年7月31日,活体器官捐献组平均随访时间为(30±7)个月,公民逝世后器官捐献组为(25±11)个月。术后公民逝世后器官捐献组移植�
Objective To compare the clinical effects of kidney transplantation between donation after citizen′s death and living organ donation at a single center.Methods Two hundred and fifty-four kidney transplant recipients who completed in the First Affiliated Hospital of Anhui Medical University from January 1,2017 to December 31,2018 and had complete follow-up data were incorporated into the study,and were divided them into living organ donation group(n=113)and the donation after citizen′s death group(n=141)according to the type of kidney donor.Sex,age,height,preoperative body weight,serum creatinine values before surgery and on the 3rd day,7th day,1 month,2 months and 12 months after surgery,as well as postoperative hospital stay of the two groups were collected.The incidence of complications such as acute rejection,delayed graft function(DGF)and pulmonary infection and the survival of the recipient/graft were observed in both groups after kidney transplantation.The measurement data of normal distribution were compared by independent sample t test.The measurement data of non-normal distribution were compared by Mann-Whitney U test.The statistical data were compared by chi-square test or Fisher′s exact probability method.The postoperative survival curves of donation after citizen′s death group and living organ donation group were drawn by Kaplan-Meier method and compared by log-rank test.A P<0.05 was considered statistically significant.Results Age,preoperative dialysis time,postoperative hospital stay,and serum creatinine at 3rd day,7th day,1 month and 2 months in living organ donation group were(32±8)years,48(42,56)months,21(22,25)d,and(195±121),(135±73),(113±53)and(115±49)μmol/L,respectively,and(42±10)years,8(15,25)months,23(30,45)d,and(483±326),(333±267),(208±160)and(172±138)μmol/L in the donation after citizen′s death group,and the difference were statistically significant(t=88.552,-7.844,-7.055,-6.129 and-2.139,Z=-7.002 and-2.810,all P<0.05).The incidence of perioperative DGF,postoperative
作者
潘佳善
朱道方
廖贵益
Pan Jiashan;Zhu Daofang;Liao Guiyi(The Fourth Ward of Urology Department(Kidney Transplantation Ward)of the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)
出处
《中华移植杂志（电子版）》
CAS
2021年第4期205-210,共6页
Chinese Journal of Transplantation(Electronic Edition)
基金
安徽医科大学基础与临床合作研究提升计划项目(2020xkjT030)。
关键词
公民逝世后器官捐献
活体器官捐献
肾移植
Donation after citizen′s death
Living organ donation
Kidney transplantation
