摘要
目的:观察生脉注射液联合超声指导下液体复苏治疗脓毒性休克的临床疗效。方法:按随机数字表法将84例脓毒性休克患者分为对照组和观察组各42例。对照组给予常规对症治疗,并实施超声指导下的液体复苏,观察组在对照组基础上加用生脉注射液治疗。比较2组治疗前后病情严重程度、T淋巴细胞亚群指标、血流动力学指标;比较2组预后情况。结果:治疗后,2组序贯器官衰竭估计评分(SOFA)、急性生理学和慢性健康状况评分Ⅱ(APACHEⅡ)均较治疗前降低(P<0.05),观察组SOFA、APACHEⅡ均低于对照组(P<0.05)。治疗后,2组血清CD3^(+)、CD4^(+)水平均较治疗前升高(P<0.05),血清CD8^(+)水平均较治疗前降低(P<0.05);观察组血清CD3^(+)、CD4^(+)水平均高于对照组(P<0.05),血清CD8^(+)水平低于对照组(P<0.05)。治疗后,2组平均动脉压(MAP)、中心静脉压(CVP)、外周血管阻力指数(SVRI)均较治疗前升高(P<0.05),观察组MAP、CVP、SVRI均高于对照组(P<0.05)。观察组机械通气时间、血管活性药物使用时间、重症监护病房(ICU)住院时间均短于对照组(P<0.05)。结论:生脉注射液联合超声指导下液体复苏治疗脓毒性休克,可改善T淋巴细胞亚群及血流动力学指标,促进疾病转归。
Objectives: To observe the clinical effect of Shengmai injection combined with ultrasound-guided fluid resuscitation for septic shock. Methods:A total of 84 cases of patients with septic shock were divided into the control group and the observation group according to the random number table method,with 42 cases in each group. The control group was given routine symptomatic treatment and ultrasound-guided fluid resuscitation, and the observation group was additionally treated with Shengmai injection based on the treatment of the control group. Before and after treatment, the severity of disease, and indexes of T lymphocyte subsets and hemodynamics in the two groups were compared. The prognosis in the two groups were compared. Results:After treatment,the scores of Sequential Organ Failure Assessment(SOFA),Acute Physiology and Chronic Health EvaluationⅡ(APACHE Ⅱ) in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of SOFA and APACHE Ⅱ in the observation group were lower than those in the control group(P<0.05). After treatment,the levels of CD3^(+)and CD4^(+)in serum in both groups were increased when compared with those before treatment(P<0.05),and the CD8^(+)level in serum was decreased(P<0.05);the levels of CD3^(+)and CD4^(+)in serum in the observation group were higher than those in the control group(P<0.05),and the CD8^(+)level in serum was lower(P<0.05). After treatment,the mean arterial pressure(MAP),central venous pressure(CVP) and systemic vascular resistance index(SVRI) in the two groups were increased when compared with those before treatment(P<0.05),and the MAP,CVP and SVRI in the observation group were higher than those in the control group(P<0.05). The time of mechanical ventilation, vasoactive drug using and intensive care unit(ICU) hospitalization in the observation group were shorter than those in the control group(P<0.05). Conclusion: Shengmai injection combined with ultrasound-guided fluid resuscitation for septic shock can improve the indexes of
作者
何涛涛
曹樟全
张洪波
HE Taotao;CAO Zhangquan;ZHANG Hongbo
出处
《新中医》
CAS
2021年第20期74-78,共5页
New Chinese Medicine
