摘要
目的探讨桃红四物汤对膝关节骨性关节炎(KOA)临床疗效、炎性因子及氧化应激的影响。方法我院收治133例KOA患者,根据治疗方案不同分为对照组68例(采用关节镜治疗)和观察组65例(采用关节镜+桃红四物汤加减治疗)。比较两组临床疗效,治疗前后炎性指标、应激反应指标、关节功能改善情况,并观察治疗过程中的安全性。结果观察组总有效率高于对照组(P<0.05);治疗后,观察组白介素4(IL-4)、白介素6(IL-6)、白介素10(IL-10)、丙二醛(MDA)水平低于对照组,超氧化物歧化酶(SOD)、γ干扰素(IFN-γ)水平高于对照组(P<0.05);治疗后两组HSS评分均有不同程度升高(P<0.05);治疗后7、14 d,观察组关节功能HSS评分均高于对照组(P<0.05)。结论对KOA患者采用桃红四物汤加减联合关节镜治疗临床疗效显著,可改善炎性反应及应激反应,能有效促进患者关节功能恢复。
Objective To explore the effect of Tao-hong-si-wu decoction on the clinical efficacy,inflammatory factors and oxidative stress of knee osteoarthritis(KOA).Methods One hundred and thirty-three KOA patients admitted to our hospital were selected.According to the difference in treatment plans,the patients were divided into a control group(n=68)with arthroscopic treatment and an observation group(n=65)with arthroscopy+Tao-hong-si-wu decoction plus/minus treatment.The clinical efficacy,inflammatory indicators,stress response indicators,and improvement of joint function before and after treatment were compared between the two groups.The safety during the treatment was also observed.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the levels of interleukin-4(IL-4),interleukin-6(IL-6),interleukin-10(IL-10)and malondialdehyde(MDA)of the observation group were lower than those of the control group,and the levels of superoxide dismutase(SOD)and interferon-γ(IFN-γ)were higher than those of the control group(P<0.05).The variance of repeated measurement showed that after treatment the Hospital for Special Surgery(HSS)scores of the two groups were both had different degrees of increase(P<0.05).After 7 days and 14 days of treatment,the HSS scores of joint function in the observation group were higher than those in the control group(P<0.05).Conclusion The treatment of KOA patients with Tao-hong-si-wu decoction combined with arthroscopy has a significant clinical effect.The treatment can improve the inflammatory response and stress response,and can effectively promote the recovery of joint function of the patients.
作者
王利云
李明艳
葛灵利
WANG Li-yun;LI Ming-yan;GE Ling-li(Shuyang Hospital of Traditional Chinese Medicine,Suqian 223600,China)
出处
《实用医院临床杂志》
2021年第6期47-50,共4页
Practical Journal of Clinical Medicine
基金
江苏省科技计划项目(编号:BM2017053)。
关键词
桃红四物汤加减
关节镜
膝关节骨性关节炎
炎性因子
氧化应激
Addition and subtraction of Tao-hong-si-wu decoction
Arthroscopy
KOA
Inflammatory factors
Oxidative stress
