摘要
铁死亡是一种新型的细胞死亡方式,是指铁依赖下的活性氧过量蓄积,导致细胞发生致死性的脂质过氧化,最终引起细胞死亡。脂肪肝对缺血再灌注损伤异常敏感,耐受性差,其发生机制尚未明确,且缺乏有效的防治手段。铁死亡与脂肪肝缺血再灌注损伤的病理生理特点有相通之处,研究其相关性可能为防治脂肪肝缺血再灌注损伤提供新的治疗策略。本文主要就铁死亡发生机制以及脂肪肝缺血再灌注损伤中与铁死亡相关靶点的研究进展进行综述。
Ferroptosis is a new type of cell death proposed in recent years.It refers to the excessive accumulation of reactive oxygen species under iron dependence,which leads to fatal lipid peroxidation of cells and ultimately leads to cell death.Fatty liver is extremely sensitive to ischemia-reperfusion injury and poorly tolerated.It’s still not understood well,and the therapeutic options are limited for the fatty liver patients.The pathophysiological characteristics of ferroptosis and fatty liver ischemia-reperfusion injury are similar,and the discovery of ferroptosis may provide a new treatment strategy for fatty liver to prevent ischemia-reperfusion injury.This article mainly reviews the mechanism of ferroptosis and the targets related to ferroptosis in fatty liver ischemia-reperfusion injury.
作者
李想
宋红丽
Li Xiang;Song Hongli(First Central Clinical College,Tianjin Medical University,Tianjin 300192,China;Department of Organ Transplantation,Tianjin First Central Hospital,Tianjin Clinical Medicine Research Center for Organ Transplantation,Key Laboratory of Transplantation Medicine,Chinese Academy of Medical Sciences,Key Laboratory of Critical Care and Emergency Medicine,National Health Commission,Tianjin 300192,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2021年第10期786-789,共4页
Chinese Journal of Hepatobiliary Surgery
基金
国家自然科学基金项目(82070639,81670574)。
关键词
脂肪肝
再灌注损伤
肝移植
铁死亡
Fatty liver
Reperfusion injury
Liver transplantation
Ferroptosis
