摘要
目的:探讨通过基础性激素联合抗苗勒管激素并结合窦卵泡数的检测对生长激素治疗早发性卵巢功能不全(POI)的效果。方法:回顾性分析2017年1月至2020年6月期间在九江市妇幼保健院生殖中心接受辅助生殖技术治疗,且诊断为早发性卵巢功能不全的患者资料,将其均分为A组和B组,每组100例患者,POI诊断标准依据2015年12月欧洲人类生殖与胚胎学会(ESHRE)的POI指南。A组为均未接受生长激素规范化治疗的早发性卵巢功能不全患者;B组为均接受生长激素药物规范化治疗3个月的早发性卵巢功能不全患者。对照组为卵巢功能正常组,100例。结果:A与对照组间结果比较如下:两组年龄差异无统计学意义(P>0.05);窦卵泡数(AFC)、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)、抗苗勒管激素(AMH)差异有统计学意义(P<0.05),但孕酮(P)水平差异无统计学意义(P>0.05),AMH与AFC呈现一致性且两者均与E2、T呈正相关(P<0.05),与FSH、LH呈明显负相关(P<0.05)。B与对照组结果比较如下:两组年龄差异无统计学意义(P>0.05);AFC、E2、FSH、T、AMH差异无统计学意义(P>0.05),但P及LH差异有统计学意义(P<0.05)。结论:通过基础性激素联合血清抗苗勒管激素和窦卵泡数,对于生长激素规范化治疗的早发性卵巢功能不全患者的卵巢储备功能的评估,可以精准的评判POI患者的药物治疗效果,为生长激素治疗POI患者提供可靠思路。
Objective:To investigate the effect of growth hormone on early-onset ovarian insufficiency(POI).Methods:The clinical data of patients diagnosed with early-onset ovarian insufficiency who received assisted reproductive technology in the Jiujiang Maternity and Child Health Care Hospital from January 2017 to June 2020 were retrospectively analyzed and equally divided into group A and group B,with 100 patients in each group.The diagnostic criteria for POI were based on the POI guidelines of the European Society of Human Reproduction and Embryology(ESHRE)in December 2015.A patients with early-onset ovarian insufficiency who did not receive standardized treatment with growth hormone;B patients with early-onset ovarian insufficiency who received standardized treatment with growth hormone drugs for 3 months.The control group consisted of 100 patients with normal ovarian function.Results:The results between A and the control group were compared as follows:there was no significant difference in age between the two groups(P>0.05);there was a significant difference in antral follicle count(AFC),follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),testosterone(T),and antimalarial hormone(AMH)(P<0.05),but there was no significant difference in progesterone(P)levels(P>0.05),AMH showed consistency with AFC and both of them were positively correlated with E2 and T,and significantly negatively correlated with FSH and LH,and the same difference was statistically significant(P<0.05).The results of B compared with the control group were as follows:there was no significant difference in age between the two groups(P>0.05);there was no significant difference in AFC,E2,FSH,T,and AMH(P>0.05),but there was a significant difference in P and LH(P<0.05).Conclusion:Through basic sex hormones combined with serum anti-hormone and antral follicle count,for the evaluation of ovarian reserve in patients with early-onset ovarian insufficiency treated with standardized growth hormone therapy,the drug treatment effect in patients wi
作者
张琴
苏占营
吴成亮
ZHANG Qin;SU Zhanying;WU Chengliang(Jiujiang Maternity and Child Health Care Hospital,Jiujiang Jiangxi 332000,China)
出处
《药品评价》
CAS
2021年第18期1118-1120,共3页
Drug Evaluation
基金
江西省重点研发计划项目(20171BBG70010)
江西省卫健委科技计划(20204241)。
