摘要
目的综合评估肥胖患者腹腔镜袖状胃切除术(Laparoscopic sleeve gastrectomy,LSG)后多项维生素和微量元素水平的变化。方法计算机检索Pubmed、Embase、Cochrane library、Web of Science,万方数据和CNKI数据库,按纳入标准和排除标准选择文献,采用Stata 13.0软件进行统计学分析。结果共纳入22篇文献,包含5320例肥胖患者。Meta分析结果表明,LSG术后血清维生素D(SMD=0.59,95%CI:0.16~1.03,P=0.007)、磷(SMD=0.28,95%CI:0.09~0.47,P=0.004)和铁(SMD=0.46,95%CI:0.31~0.61,P<0.01)显著升高,而血清锌(SMD=-0.41,95%CI:-0.81~-0.01,P=0.044)显著下降。血清钙(SMD=0.11,95%CI:-0.14~0.36,P=0.385)、叶酸(SMD=0.27,95%CI:-0.08~0.62,P=0.133)、维生素B12(SMD=0.11,95%CI:-0.25~0.47,P=0.563)和镁(SMD=0.53,95%CI:-0.08~1.14,P=0.09)无显著性改变。结论肥胖患者LSG术后血清营养指标改变尚存在不确定性,建议定期监测血清营养指标变化并在必要时添加补充剂,以预防术后营养不良。
Objective To evaluate the changes in vitamins and trace elements in obese patients after laparoscopic sleeve gastrectomy(LSG).Methods A systematic retrieval of the available literature was performed using Pubmed,Embase,Cochrane library,Web of Science,WanFang data and CNKI databases and studies were selected per predefined eligibility criteria.Statistical analysis was performed using Stata 13.0.Results A total of 22 studies with 5320 individuals with obesity who underwent LSG were identified as eligible for inclusion.A significant increase was observed in serum 25(OH)D(SMD=0.59,95%CI:0.16 to 1.03,P=0.007),phosphorus(SMD=0.28,95%CI:0.09 to 0.47,P=0.004)and iron(SMD=0.46,95%CI:0.31 to 0.61,P<0.01)after LSG.A significant decrease in serum zinc(SMD=-0.41,95%CI:-0.81 to-0.01,P=0.044)was observed after LSG.But no significant changes in serum calcium(SMD=0.11,95%CI:-0.14 to 0.36,P=0.385),folate(SMD=0.27,95%CI:-0.08 to 0.62,P=0.133),vitamin B12(SMD=0.11,95%CI:-0.25 to 0.47,P=0.563)and magnesium(SMD=0.53,95%CI:-0.08 to 1.14,P=0.09)were observed.Conclusions The changes of serum nutritional measurements in individuals with obesity who underwent LSG are uncertain.Therefore,it is recommended to monitor the nutritional laboratory values and add supplements when necessary to prevent postoperative malnutrition.
作者
王艳
段雷振
韩雪
王瑾瑾
闫国立
Wang Yan;Duan Leizhen;Han Xue;Wang Jinjin;Yan Guoli(Public Health and Preventive Medicine Teaching and Research Center,Henan University of Chinese Medicine,Zhengzhou 450046,China;Department of Medical Services,Zhengzhou Central Hospital affiliated to Zhengzhou University,Zhengzhou 450000,China)
出处
《中华临床营养杂志》
CAS
CSCD
2021年第4期201-209,共9页
Chinese Journal of Clinical Nutrition
