摘要
目的评价补肾消癃汤联合坦洛新治疗良性前列腺增生症的疗效及对血清睾酮(T)、雌二醇(E_(2))的影响。方法选取2018年1月至2019年12月北京中医药大学房山医院诊治的70例良性前列腺增生症患者作为研究对象,采用随机数字表法分为治疗组(n=35)和对照组(n=35)。治疗组采用补肾消癃汤+坦洛新治疗,对照组采用单纯坦洛新治疗,疗程8周,停药后随访2周。观察两组治疗前后国际前列腺症状评分(IPSS)、生活质量评分(QOL)、最大尿流率(Q_(max))、膀胱残余尿量(PVR)、前列腺体积(PV)、中医证候积分、T和E_(2)水平,以及停药2周后IPSS,记录不良反应。结果对照组完成治疗30例,总有效率66.7%,显效率30.0%;治疗组完成32例,总有效率87.5%,显效率62.5%;两组疗效差异具有统计学意义(P<0.05)。两组治疗后除PV无明显变化(P>0.05),IPSS、QOL、Q_(max)、PVR、中医证候积分均有明显改善(P<0.05);治疗组在IPSS、QOL、Q_(max)、PVR、中医证候积分方面改善明显优于对照组(P<0.05)。治疗组血清T、E_(2)及T/E_(2)变化显著(P<0.05),对照组无显著变化(P>0.05)。治疗组停药2周后IPSS较停药前无明显变化(P>0.05),对照组停药2周后IPSS较停药前明显升高(P<0.05)。结论补肾消癃汤联合坦洛新可明显改善BPH临床症状,显著提高临床疗效,并且具有一定的停药稳定性,对血清T、E_(2)水平有显著影响。
Objective To evaluate the efficacy of Bushen Xiaolong Decoction combined with Tamlosin in the treatment of benign prostatic hyperplasia and the effects on serum testosterone(T)and estradiol(E_(2)).Methods 70 patients with benign prostatic hyperplasia treated in Fangshan Hospital,Beijing University of Traditional Chinese Medicine from January 2018 to December 2019 were selected and divided into treatment group(n=35)and control group(n=35)by random number table method.The treatment group was treated with Bushen Xiaolong Decoction+Tamlosin,while the control group with tamlosin alone,each for eight weeks,follow up for 2 weeks.International prostate symptom score(IPSS),quality of life score(QOL),maximum urine flow rate(Q_(max)),bladder residual urine volume(PVR),prostate volume(PV),TCM syndrome score,T and E_(2)levels and IPSS 2 weeks after drug withdrawal were observed before and after treatment,and adverse reactions were recorded.Results We complete 30 cases in control group and 32 cases in treatment group finally.The control group total effective rate 66.7%,significant efficiency 30.0%and the treatment group total effective rate 87.5%,significant efficiency 62.5%.The two groups have significant difference in efficacy(P<0.05).After treatment,IPSS,QOL,Q_(max),PVR and TCM syndrome scores were significantly improved except PV(P>0.05).IPSS,QOL,Q_(max),PVR and TCM syndrome score in the treatment group were significantly better than those in the control group(P<0.05).The changes of serum T,E_(2)and T/E_(2)in treatment group were significant(P<0.05),but not in control group(P>0.05).There was no significant change in IPSS in the treatment group 2 weeks after drug withdrawal compared with that before drug withdrawal(P>0.05),and IPSS in the control group 2 weeks after drug withdrawal was significantly higher than that before drug withdrawal(P<0.05).Conclusions Bushen Xiaolong Decoction combined with Tamsulosin can obviously improve the clinical symptoms of BPH and clinical efficacy significantly,which has a certain drug withd
作者
韩亮
李海松
祝雨田
张新荣
陈朝晖
周文亮
刘清尧
HAN Liang;LI Haisong;ZHU Yutian;ZHANG Xinrong;CHEN Zhaohui;ZHOU Wenliang;LIU Qingyao(Department of Andrology,First Clinical Medical College,Beijing University of Traditional Chinese Medicine,Beijing 100700,China;Department of Andrology,Fangshan Hospital,Beijing University of Traditional Chinese Medicine,Beijing 102400,China;Department of Traditional Chinese Medicine,Peking University Third Hospital,Beijing 100191,China)
出处
《中国性科学》
2021年第10期126-129,共4页
Chinese Journal of Human Sexuality
基金
北京市房山区优秀人才项目(2016000000007G011)
北京市优秀人才项目(2018000077606G483)。
关键词
补肾消癃汤
前列腺增生症
肾虚血瘀证
生殖激素
临床研究
Bushen Xiaolong Decoction
Prostate hyperplasia
Kidney deficiency blood stasis syndrome
Reproductive hormone
Clinical research
