摘要
在卵母细胞体外成熟和胚胎发育过程中,细胞代谢产生大量的活性氧(ROS),而ROS过量积累是导致体外成熟卵母细胞的质量及发育潜力低于体内卵母细胞的主要原因之一。褪黑素作为一种有效的ROS清除剂,具有抗氧化性,能为暴露在大量ROS下的细胞器提供保护作用。本文综述了褪黑素对卵母细胞和多种细胞器的保护作用及机制,为其在动物胚胎生产和动物繁殖中更广泛应用提供参考。
A large amount of reactive oxygen species(ROS)is generated during oocyte maturation and embryo development in vitro.However,the excessive ROS accumulation is one of the main reasons why the oocytes matured in vitro possess lower quality and developmental potential than those in vivo.As an effective ROS scavenger,melatonin has autoxidation activity and protects cell organelles exposed to ROS from damage.This article reviewed the protective effects and mechanisms of melatonin on oocytes and cell organelles,which will provide a reference for the wider application of melatonin in embryo production and animal reproduction.
作者
田雅晴
王婉洁
郝海生
邹惠影
庞云渭
赵学明
赵善江
朱化彬
杜卫华
TIAN Yaqing;WANG Wanjie;HAO Haisheng;ZOU Huiying;PANG Yunwei;ZHAO Xueming;ZHAO Shanjiang;ZHU Huabin;DU Weihua(Laboratory of Embryo Engineering Technology,Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,China)
出处
《中国畜牧杂志》
CAS
北大核心
2021年第11期1-5,共5页
Chinese Journal of Animal Science
基金
中国农业科学院科技创新工程项目(ASTIP-IAS06)
转基因重大专项(2018ZX08007001)。
