摘要
1例53岁女性患者因泌尿系感染给予注射用美罗培南1 g静脉滴注、1次/8 h。用药前血小板计数(PLT)151×10^(9)/L;使用美罗培南第9天,实验室检查示PLT 577×10^(9)/L;使用该药第12天,患者感染得到控制,但PLT升高至829×10^(9)/L。考虑血小板增多可能与美罗培南有关,停用该药,换为注射用哌拉西林钠舒巴坦钠5 g入0.9%氯化钠注射液100 ml静脉滴注、1次/8 h。3 d后PLT降至782×10^(9)/L,23 d后PLT降至272×10^(9)/L。
A 53‑year‑old female patient received IV infusion of meropenem for injection 1.0 g once every 8 hours for urinary tract infection.Her platelet count(PLT)was 151×10^(9)/L before using meropenem.On the 9th day of meropenem treatment,the laboratory test showed PLT 577×10^(9)/L and on the 12th day,the patient′s infection was controlled but PLT increased to 829×10^(9)/L.The thrombocytosis related to meropenem was considered.Meropenem was stopped and replaced by IV infusion of piperacillin sodium and sulbactam sodium for injection 5 g dissolved in 100 ml of 0.9%sodium chloride injection once 8 hours.Three days later,the patient′s PLT decreased to 782×10^(9)/L;23 days later,PLT was 272×10^(9)/L.
作者
刘彦儒
贺艳菊
Liu Yanru;He Yanju(Department of Pharmacy,Shanghai Pudong Hospital,Fudan University Pudong Medical Center,Shanghai 201399,China;Department of Endocrinology,Shanghai Pudong Hospital,Fudan University Pudong Medical Center,Shanghai 201399,China)
出处
《药物不良反应杂志》
CSCD
2021年第10期544-545,共2页
Adverse Drug Reactions Journal
基金
复旦大学附属浦东医院院级课题(YJ2020‑10)。
