摘要
醛固酮还原酶(Aldo-keto reductase family 1 member C3,AKR1C3)是一种人类细胞内的多功能酶,广泛表达于肝脏、肺、前列腺、睾丸和乳腺组织等,主要参与类固醇激素的代谢,可以保护人体细胞。然而,近年来一系列的研究发现,AKR1C3在多种肿瘤细胞中呈高表达状态,通过影响血管生成等促进了肿瘤的发生、发展,并且与其不良预后密切相关;此外,AKR1C3还与多种抗肿瘤治疗(包括放疗、化疗和分子靶向治疗等)的耐药有关。深入研究AKR1C3及其抑制剂,以开发新的治疗方法和药物,可能具有重要的科学意义和潜在的实用价值。因此,本文总结和分析了AKR1C3与恶性肿瘤关系的有关研究进展。
Aldo-keto reductase family 1member C3(AKR1C3)is a multifunctional enzyme in human cells,which is widely expressed in liver,lung,prostate,testis and breast tissues.It is mainly involved in the metabolism of steroid hormones and can protect human cells.However,in recent years,a series of studies have found that AKR1C3 is highly expressed in a variety of tumor cells.Meanwhile,it can promote tumorigenesis,development by ways like anaiogenesis and is closely related to its poor prognosis.in addition,AKR1C3 is also associated with resistance to a variety of antitumor therapies(including radiotherapy,chemotherapy and molecular targeted therapy).Deep study of AKR1C3 and its inhibitors in order to develop new therapeutic methods and drugs may have important scientific significance and potential practical value.Therefore,this paper summarizes and analyzes the relevant research progression on the relationship between AKR1C3 and malignant tumors.
作者
张玉
秦叔逵
ZHANG Yu;QIN Shukui(Bayi Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 210029, China)
出处
《临床肿瘤学杂志》
CAS
2021年第10期935-941,共7页
Chinese Clinical Oncology
