摘要
目的探讨成纤维细胞生长因子-23(FGF-23)、生长刺激表达基因2蛋白(ST2)、CXC型趋化因子配体16(CXCL16)在舒张性心力衰竭(DHF)患者中表达及临床意义。方法选取2019年6月至2020年12月本院收治的108例DHF患者(DHF组)及50例健康对照人群(对照组),比较两组人口学资料、FGF-23、ST2、CXCL16,比较不同舒张功能受损程度者人口学资料、FGF-23、ST2、CXCL16,采用Spearman分析、多分类Logistic回归方程分析、受试者工作特征曲线(ROC)及ROC下面积(AUC)分析分析处理数据。结果DHF组FGF-23、ST2、CXCL16高于对照组,差异有统计学意义(P<0.05);房颤、E/A、左室收缩末内径、FGF-23、ST2、CXCL16:重度>中度>轻度,差异有统计学意义(P<0.05);FGF-23(r=0.818,P<0.05)、ST2(r=0.754,P<0.05)、CXCL16(r=0.706,P<0.05)与舒张功能受损程度呈正相关;多分类Logistic回归方程分析,结果显示,将房颤、E/A、左室收缩末内径控制后,FGF-23、ST2、CXCL16仍与舒张功能受损程度相关(P<0.05);FGF-23、ST2、CXCL16及联合预测舒张功能重度受损的AUC依次为0.820、0.827、0.764、0.954(P<0.05)。结论FGF-23、ST2、CXCL16在DHF患者中水平升高,并与心脏舒张功能受损程度有关,可作为评价心脏舒张功能的生物标志物。
Objective To investigate the expression and clinical significance of fibroblast growth factor-23(FGF-23),growth stimulation expression gene 2(ST2),CXC chemokine ligand 16(CXCL16)in patients with diastolic heart failure(DHF).Methods A total of 108 DHF patients(DHF group)and 50 healthy controls(control group)who were admitted to our hospital from June 2019 to December 2020 were selected.The demographic data,FGF-23,ST2,and CXCL16 of the two groups were compared,and the demographic data,FGF-23,ST2,and CXCL16 of people with different degrees of diastolic dysfunction were compared.Spearman analysis,multi-class logistic regression equation analysis,receiver operating characteristic curve(ROC)and area under ROC(AUC)were used to analyze and process the data.Results FGF-23,ST2 and CXCL16 in the DHF group were higher than those in the control group(P<0.05).Comparison of atrial fibrillation,E/A,left ventricular end systolic diameter,FGF-23,ST2,and CXCL16:severe>moderate>mild(P<0.05).FGF-23(r=0.818,P<0.001),ST2(r=0.754,P<0.001),CXCL16(r=0.706,P<0.001)were positively correlated with the degree of diastolic function impairment.Multi-class Logistic regression analysis showed that after controlling the atrial fibrillation,E/A,and left ventricular end-systolic diameter,FGF-23,ST2,and CXCL16 were still related to the degree of diastolic function impairment(P<0.05).The AUC of FGF-23,ST2,CXCL16 and the combination predicting severely impaired diastolic function were 0.820,0.827,0.764,0.954,respectively.Conclusion The levels of FGF-23,ST2,and CXCL16 are elevated in patients with DHF and are related to the degree of impaired diastolic function.They can be used as biomarkers for evaluating diastolic function.
作者
吕书华
冯海娟
郭卫丽
LV Shuhua;FENG Haijuan;GUO Weili(Department of Emergency,Zhengzhou Seventh People's Hospital,Zhengzhou,Henan,China,450000)
出处
《分子诊断与治疗杂志》
2021年第10期1615-1618,1622,共5页
Journal of Molecular Diagnostics and Therapy
基金
河南省医学科技攻关联合共建项目(2018020858)。
