摘要
目的:探讨突触素(Syn)、嗜铬粒素A(CgA)、核增殖抗原表达基因(Ki67)在胃肠胰神经内分泌肿瘤(GEP-NEN)患者中的表达及其与临床特征的相关性。方法:选取70例GEP-NEN患者作为研究对象,分析Syn、CgA、Ki67在GEP-NEN患者中的表达及其与临床特征的相关性。结果:70例GEP-NEN患者中,Syn阳性62例,CgA阳性55例,Ki67阳性32例;Syn在不同临床特征GEP-NEN患者中的阳性率表达比较,差异均无统计学意义(P>0.05);CgA在不同肿瘤部位、不同肿瘤直径、有无远处转移GEP-NEN患者中的阳性表达率比较,差异均无统计学意义(P>0.05);Ⅲ~Ⅳ期和有淋巴结转移的GEP-NEN患者CgA阳性表达率较高,差异有统计学意义(P<0.05);Ki67在不同肿瘤部位GEP-NEN患者中的阳性表达率比较,差异无统计学意义(P>0.05);肿瘤直径≥2 cm、Ⅲ~Ⅳ期、有淋巴结转移和有远处转移的GEP-NEN患者Ki67阳性表达率均较高,差异有统计学意义(P<0.05);经Kendall's tau-b相关分析显示,CgA表达水平与GEP-NEN肿瘤分期和有淋巴结转移呈正相关,Ki67表达水平与GEP-NEN肿瘤直径、肿瘤分期、淋巴结转移和远处转移均呈正相关(P<0.05)。结论:Syn在GEP-NEN患者中呈高表达,但在不同临床特征的GEP-NEN患者中差异不明显;CgA水平与GEP-NEN患者肿瘤分期和淋巴结转移呈正相关,Ki67水平与GEP-NEN患者肿瘤直径、肿瘤分期、淋巴结转移和远处转移均呈正相关。
Objective:To explore expressions of synaptophysin(Syn),chromogranin A(CgA)and proliferating cell nuclear antigen expression gene(Ki67)in patients with gastrointestinal pancreatic neuroendocrine tumors(GEP-NEN)and their clinical correlations.Methods:70 GEP-NEN patients were selected as the research objects.The expression of Syn,CgA and Ki67 in these GEP-NEN patients and their clinical correlations were analyzed.Results:Among the 70 GEP-NEN patients,62 were Syn-positive,55 were CgA-positive,and 32 were Ki67-positive.There was no statistically significant difference in the positive expression rate of Syn in the GEP-NEN patients with different clinical characteristics(P>0.05).There was no statistically significant difference in the positive expression rate of CgA in the GEP-NEN patients with different tumor sites,different tumor diameters,and with or without distant metastases(P>0.05).The positive expression rate of CgA in the GEP-NEN patients with stage III-IV and lymph node metastasis was higher,and the difference was statistically significant(P<0.05).There was no significant difference in the positive expression rate of Ki67 in the GEP-NEN patients with different tumor sites(P>0.05).The positive expression rates of Ki67 in the GEP-NEN patients with tumor diameter≥2 cm,stage III-IV,lymph node metastases and distant metastases were all higher,and the difference were statistically significant(P<0.05).Kendall’s tau-b correlation coefficient analysis showed that the CgA expression level was positively correlated with the GEP-NEN tumor staging and lymph node metastases,and the Ki67 expression level was positively correlated with the GEP-NEN tumor diameter,tumor staging,lymph node metastases and distant metastases(P<0.05).Conclusions:Syn is highly expressed in the GEP-NEN patients,but there is no significant difference in the Syn level in the GEP-NEN patients with different clinical characteristics.The CgA level is positively correlated with the tumor staging and lymph node metastases in the GEP-NEN patients.Further,
作者
闫玉玲
YAN Yuling(Department of Pathology of Shangqiu City Hospital of Traditional Chinese Medicine,Shangqiu 476000 Henan,China)
出处
《中国民康医学》
2021年第19期1-4,共4页
Medical Journal of Chinese People’s Health
关键词
胃肠胰神经内分泌肿瘤
突触素
嗜铬粒素A
核增殖抗原表达基因
临床特征
相关性
Gastrointestinal pancreatic neuroendocrine tumor
Synaptophysin
Chromogranin A
Proliferating cell nuclear antigen expression gene
Clinical characteristic
Correlation