期刊文献+

Syn、CgA、Ki67在胃肠胰神经内分泌肿瘤患者中的表达及其与临床特征的相关性 被引量:1

Expressions of Syn,CgA and Ki67 in patients with gastrointestinal pancreatic neuroendocrine tumors and their clinical correlations
下载PDF
导出
摘要 目的:探讨突触素(Syn)、嗜铬粒素A(CgA)、核增殖抗原表达基因(Ki67)在胃肠胰神经内分泌肿瘤(GEP-NEN)患者中的表达及其与临床特征的相关性。方法:选取70例GEP-NEN患者作为研究对象,分析Syn、CgA、Ki67在GEP-NEN患者中的表达及其与临床特征的相关性。结果:70例GEP-NEN患者中,Syn阳性62例,CgA阳性55例,Ki67阳性32例;Syn在不同临床特征GEP-NEN患者中的阳性率表达比较,差异均无统计学意义(P>0.05);CgA在不同肿瘤部位、不同肿瘤直径、有无远处转移GEP-NEN患者中的阳性表达率比较,差异均无统计学意义(P>0.05);Ⅲ~Ⅳ期和有淋巴结转移的GEP-NEN患者CgA阳性表达率较高,差异有统计学意义(P<0.05);Ki67在不同肿瘤部位GEP-NEN患者中的阳性表达率比较,差异无统计学意义(P>0.05);肿瘤直径≥2 cm、Ⅲ~Ⅳ期、有淋巴结转移和有远处转移的GEP-NEN患者Ki67阳性表达率均较高,差异有统计学意义(P<0.05);经Kendall's tau-b相关分析显示,CgA表达水平与GEP-NEN肿瘤分期和有淋巴结转移呈正相关,Ki67表达水平与GEP-NEN肿瘤直径、肿瘤分期、淋巴结转移和远处转移均呈正相关(P<0.05)。结论:Syn在GEP-NEN患者中呈高表达,但在不同临床特征的GEP-NEN患者中差异不明显;CgA水平与GEP-NEN患者肿瘤分期和淋巴结转移呈正相关,Ki67水平与GEP-NEN患者肿瘤直径、肿瘤分期、淋巴结转移和远处转移均呈正相关。 Objective:To explore expressions of synaptophysin(Syn),chromogranin A(CgA)and proliferating cell nuclear antigen expression gene(Ki67)in patients with gastrointestinal pancreatic neuroendocrine tumors(GEP-NEN)and their clinical correlations.Methods:70 GEP-NEN patients were selected as the research objects.The expression of Syn,CgA and Ki67 in these GEP-NEN patients and their clinical correlations were analyzed.Results:Among the 70 GEP-NEN patients,62 were Syn-positive,55 were CgA-positive,and 32 were Ki67-positive.There was no statistically significant difference in the positive expression rate of Syn in the GEP-NEN patients with different clinical characteristics(P>0.05).There was no statistically significant difference in the positive expression rate of CgA in the GEP-NEN patients with different tumor sites,different tumor diameters,and with or without distant metastases(P>0.05).The positive expression rate of CgA in the GEP-NEN patients with stage III-IV and lymph node metastasis was higher,and the difference was statistically significant(P<0.05).There was no significant difference in the positive expression rate of Ki67 in the GEP-NEN patients with different tumor sites(P>0.05).The positive expression rates of Ki67 in the GEP-NEN patients with tumor diameter≥2 cm,stage III-IV,lymph node metastases and distant metastases were all higher,and the difference were statistically significant(P<0.05).Kendall’s tau-b correlation coefficient analysis showed that the CgA expression level was positively correlated with the GEP-NEN tumor staging and lymph node metastases,and the Ki67 expression level was positively correlated with the GEP-NEN tumor diameter,tumor staging,lymph node metastases and distant metastases(P<0.05).Conclusions:Syn is highly expressed in the GEP-NEN patients,but there is no significant difference in the Syn level in the GEP-NEN patients with different clinical characteristics.The CgA level is positively correlated with the tumor staging and lymph node metastases in the GEP-NEN patients.Further,
作者 闫玉玲 YAN Yuling(Department of Pathology of Shangqiu City Hospital of Traditional Chinese Medicine,Shangqiu 476000 Henan,China)
出处 《中国民康医学》 2021年第19期1-4,共4页 Medical Journal of Chinese People’s Health
关键词 胃肠胰神经内分泌肿瘤 突触素 嗜铬粒素A 核增殖抗原表达基因 临床特征 相关性 Gastrointestinal pancreatic neuroendocrine tumor Synaptophysin Chromogranin A Proliferating cell nuclear antigen expression gene Clinical characteristic Correlation
  • 相关文献

参考文献8

二级参考文献67

  • 1Simona Grozinsky-Glasberg,Dimitrios Thomas,Jonathan R Strosberg,Ulrich-Frank Pape,Stephan Felder,Apostolos V Tsolakis,Krystallenia I Alexandraki,Merav Fraenkel,Leonard Saiegh,Petachia Reissman,Gregory Kaltsas,David J Gross.Metastatic type 1 gastric carcinoid:A real threat or just a myth?[J].World Journal of Gastroenterology,2013,19(46):8687-8695. 被引量:12
  • 2Martin Anlauf,Nele Garbrecht,Tobias Henopp,Anja Schmitt,Regina Schlenger,Andreas Raffel,Markus Krausch,Oliver Gimm,Claus F Eisenberger,Wolfram T Knoefel,Henning Dralle,Paul Komminoth,Philipp U Heitz,Aurel Perren,Günter Klppel.Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features[J].World Journal of Gastroenterology,2006,12(34):5440-5446. 被引量:7
  • 3岳欣,顾锋,夏维波,萧新华,李梅,邢小平,曾正陪,向红丁,连小兰,伍学焱.胰岛素瘤的术前定性及定位诊断99例分析[J].中国实用内科杂志:临床前沿版,2006,26(11):1795-1797. 被引量:16
  • 4Yaov JC,Hassan M,Phan A,et al.One hundred years after "carcinoid ":epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States.J Clin Oncol,2008,26(18):3063-3072. 被引量:1
  • 5Yao JC,Shah MH,Ito T,et al.Everolimus for advanced pancreatic neuroendocrine tumors.N Engl J Med,2011,364(6):514-523. 被引量:1
  • 6Raymond E,Dahan L,Raoul JL,et al.Sunitinib malate for the treatment of pancreatic neuroendocrine tumors.N Engl J Med,2011,36(6):501-513. 被引量:1
  • 7Kl(o)ppel G,Couvelard A,Perren A,et al.ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors:towards a standardized approach to the diagnosis of gastroenteropancreatic neuroendocrine tumors and their prognostic stratification.Neuroendocrinology,2009,90 (2):162-166. 被引量:1
  • 8Klimstra DS,Modlin IR,Adsay NV,et al.Pathology reporting of neuroendocrine tumors:application of the Delphic consensus process to the development of a minimum pathology data set.Am J Surg Pathol,2010,34(3):300-313. 被引量:1
  • 9Bosman FT,Carneiro F,Hruban RH,et al.WHO classification of tumours of the digestive system.Lyon:IARC Press,2010. 被引量:1
  • 10Oberndorfer S.Karzinoide tumoren des dunndarms.Frankf ZPatrol,1907,1:426-432. 被引量:1

共引文献512

同被引文献6

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部