摘要
目的分析本地和外地生源高中新生在入学时和入学一年后的结核感染状况及其动态变化。方法于2019年在广西壮族自治区南宁市选择两所示范性寄宿制高中入学的全体新生,采用结核菌素皮肤试验(tuberculin skin test,TST)进行入学时结核病筛查,连续观察1年后再次进行TST试验和现场调查。结核感染状态变化用TST试验转阳来表示。多因素Logistic回归模型分析不同生源地对学生TST试验转阳的影响。结果总共1 877名学生接受TST试验,其中本地生源学生1 482名,外地生源学生395名。在入学时,外地生源学生TST总阳性率(8.6%)低于本地生源(10.7%),非参数秩和检验显示,入学时本地生源和外地生源高中生TST试验结果总体差异有统计学意义(P<0.001)。入学一年后,外地生源学生有78人TST试验出现转阳情况,估算结核新发感染率为21.0%(95%CI:16.99%~25.53%)。本地生源学生有167人TST试验出现转阳情况,结核新发感染率为11.8%(95%CI:10.15%~13.58%)。多因素Logistic回归分析结果显示,相比于本地生源学生,入学一年后外地生源学生的TST试验出现转阳的风险显著增加了1.67倍(95%CI:1.22~2.28)。结论入学一年后,本地、外地生源结核感染增加,且外地生源的结核新发感染风险明显高于本地生源学生。
Objective To explore the TB infection status and dynamic changes of high school freshmen from local and non-local at the time of enrollment and one year after enrollment.Methods In 2019, all freshmen enrolled in two demonstration boarding high schools were selected in Nanning City, Guangxi. Tuberculin skin test(TST) was used for tuberculosis screening at school. After continuous observation for one year, TST and investigation were performed again. The change of tuberculosis infection status was indicated by the positive conversion of TST. Multivariate Logistic regression model was used to analyze the influence of different student origin places on the positive conversion of TST.Results A total of 1877 students received the TST, 1 482 were the local students and 395 were the non-local students. At the time of enrollment,the total positive rate of TST of high school students from non-local was lower than that of local students(8.6% vs 10.7%), Nonparametric rank-sum test showed that there was a statistically significant difference in TST test results between local and nonlocal high school students when admission(P<0.001). After one year of enrollment, the TST appeared positive in 78 students from non-local, the estimated rate of new TB infection was 21.0%(95%CI: 16.99%-25.53%). The TST appeared positive in167 local students, with a new TB infection rate of 11.8%(95%CI: 10.15%-13.58%). Multivariate Logistic regression analysis showed that compared with the local students, the risk of TST convert to positive of non-local students was significantly increased by 1.67 times(95%CI: 1.22-2.28) one year after enrollment.Conclusion After one year of enrollment, the TB infection of local and non-local students were increased, and the risk of new TB infection of non-local student was significantly higher than that of local student.
作者
潘冬香
崔哲哲
覃慧芳
蓝如束
PAN Dong-xiang;CUI Zhe-zhe;QIN Hui-fang;LAN Ru-shu(Department of Pediatrics and Maternal and Child Health,School of Public Health,Guangxi Medical University,Nanning,Guangxi 530021,China;Tuberculosis Control Institute,Guangxi Center for Disease Control and Prevention,Nanning,Guangxi 530021,China;Department of Clinical Laboratory,Jiangbin Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangxi 530012,China)
出处
《中国热带医学》
CAS
2021年第10期939-942,共4页
China Tropical Medicine
基金
广西自然科学基金项目(No.2019GXNSFAA245094)。
关键词
结核
高中生
生源地
结核菌素皮肤试验
随访筛查
Tuberculosis
high school student
students to translate
tuberculin skin test
follow-up screening
