摘要
聚醚离子抗生素(polyether ionophore antibiotics)可以与金属阳离子形成脂溶性复合物进行跨生物膜运输,长期以来一直被用作家禽的抗球虫药物和反刍动物的生长促进剂。近年研究发现部分聚醚离子抗生素具有抗肿瘤活性,其抗肿瘤作用与自噬(autophagy)有关。现综述聚醚离子抗生素对不同肿瘤细胞自噬的影响,分析其诱导或抑制自噬的多种影响因素及信号通路,以期为聚醚离子抗生素的临床应用提供一定的理论依据。
Polyether ionophore antibiotics can form fat-soluble complexes with metal cations and transport them across cellular membranes,which have been used as anticoccidial drugs for poultry and growth promoters for ruminants.Recently,some polyether ionophore antibiotics exert their anti-tumor activities,at least partially,through cell autophagy.In this review,the effects of polyether ionophore antibiotics on autophagy in different tumor cells were reviewed,and various influencing factors and signaling pathways of the induction or inhibition of autophagy were analyzed,aiming to raise exciting possibilities for the clinical application of polyether ionophore antibiotics.
作者
戚志敏
赵云峰
QI Zhi-Min;ZHAO Yun-Feng(School of Life Science,Qufu Normal University,Qufu 273165,China)
出处
《生命科学》
CSCD
北大核心
2021年第8期1010-1017,共8页
Chinese Bulletin of Life Sciences
基金
细胞生物学研究生优质课(SDYKC19188)。
关键词
聚醚离子抗生素
自噬
肿瘤
polyether ionophore antibiotics
autophagy
cancer
