摘要
目的:探讨复方甘草酸苷注射液和异甘草酸镁注射液对胆总管结石术前改善肝功能的效果。方法:2017年1月-2021年1月收治胆总管结石并黄疸患者101例,均行胆总管切开取石手术;分为两组。观察组术前应用复方甘草酸苷;对照组术前应用异甘草酸镁。比较两组患者术前肝功能指标水平及不良反应情况。结果:观察组治疗后总胆红素(TBIL)、直接胆红素(DBIL)及间接胆红素(IDBIL)水平均低于对照组,差异有统计学意义(P<0.05);两组治疗后谷丙转氨酶(ALT)及谷草转氨酶(AST)水平比较,差异无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对胆总管结石引起的黄疸患者术前短期采用复方甘草酸苷和异甘草酸镁治疗,均能够获得一定效果,其中复方甘草酸苷的降黄效果更加显著,不会增加患者的不良反应,安全性较好,利于临床推广应用。
Objective:To investigate the effect of compound glycyrrhizin injection and magnesium isoglycyrrhizinate injection on the improvement of liver function before choledocholithiasis surgery.Methods:From January 2017 to January 2021,101 patients with choledocholithiasis and jaundice were selected.All of them underwent choledocholithotomy and stone removal.They were divided into the two groups.The observation group was treated with compound glycyrrhizin before operation.The control group was treated with magnesium isoglycyrrhizinate before operation.The liver function index levels before operation and adverse reactions were compared between the two group.Results:The levels of total bilirubin(TBIL),direct bilirubin(DBIL)and indirect bilirubin(IDBIL)in the observation group after treatment were lower than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)between the two groups after treatment(P>0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:For patients with jaundice caused by common bile duct stones,short-term preoperative treatment with compound glycyrrhizin and magnesium isoglycyrrhizin can achieve certain effects.Among them,compound glycyrrhizin has a more significant effect on reducing jaundice,and does not increase the patient’s adverse reactions.The safety is good,which is conducive to clinical promotion and application.
作者
沈卡
周建波
王佳
彭纲
Shen Ka;Zhou Jianbo;Wang Jia;Peng Gang(Graduate Training Base of Jinzhou Medical University(Suizhou Hospital Affiliated to Hubei Medical College),Hubei Suizhou 441300)
出处
《中国社区医师》
2021年第31期77-78,共2页
Chinese Community Doctors
关键词
复方甘草酸苷
异甘草酸镁
胆总管结石
肝功能
临床疗效
Compound glycyrrhizin
Magnesium isoglycyrrhizinate
Choledocholithiasis
Liver function
Clinical efficacy
