摘要
目的观察青紫合剂联合常规西医治疗过敏性紫癜(HSP)的疗效。方法选取2017年3月—2019年2月榆林市中医医院收治的140例HSP患儿。采用随机数字表法分为治疗组和对照组,每组70例。对照组予以常规西医治疗,治疗组在对照组基础上加用青紫合剂,两组均连续治疗14 d。观察两组临床疗效、各临床症状消失时间,以及治疗前后测定HSP患儿血常规、凝血功能、C反应蛋白(CRP)、红细胞沉降率(ESR)及免疫功能等,记录不良反应发生情况。结果治疗组患儿治疗后总有效率高于对照组(88.57%VS77.14%)(P<0.05);而皮疹消退时间、腹痛消失时间、消化道症状缓解时间及关节症状缓解时间短于对照组(P<0.05)。治疗组患儿治疗后ESR、免疫球蛋白A、免疫球蛋白G、白细胞计数、血小板、D-二聚体及CRP均低于对照组(P<0.05)。结论青紫合剂联合西医治疗HSP患儿疗效确切,能够有效改善患儿临床症状及实验室指标。
Objective To observe the curative effect of Qingzi Mixture combined with routine western medicine on Henoch-Schonlein purpura(HSP).Methods A total of 140 children with HSP who were admitted to our hospital from March 2017 to February 2019 were enrolled.They were divided into treatment group and control group by random number table method,with 70 cases in each group.The control group was given routine western medicine alone,while the treatment group was given Qingzi Mixture on the basis of control group.The two groups were continuously treated for 14 d.The clinical curative effect and time to symptom disappearance in both groups were observed.The blood routine,coagulation function,C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)and immune function of children with HSP were measured before and after treatment.The occurrence of adverse reactions was recorded.Results The total response rate of treatment group was higher than that of control group(88.57%vs.77.14%)(P<0.05),while the time to disappearance of skin rash and abdominal pain and the time to remission of digestive and articular manifestations in treatment group were shorter than those in control group(P<0.05).After treatment,the levels of ESR,IgA,IgG,WBC,PLT,D-dimer and CRP in treatment group were lower than those in control group(P<0.05).Conclusions Qingzi Mixture combined with western medicine is effective for the treatment of HSP in children by improving clinical symptoms and relevant laboratory indicators.
作者
任彦林
鱼天英
王赖儿
Yan-lin Ren;Tian-ying Yu;Lai-er Wang(Yulin Traditional Chinese Medicine Hospital,Yulin,Shaanxi 719000,China)
出处
《中国现代医学杂志》
CAS
北大核心
2021年第20期86-90,共5页
China Journal of Modern Medicine
