摘要
目的:评价我国报道的精神药物相关死亡病例的特征及规律,为防治精神药物严重不良反应提供参考。方法:检索文献,统计我国中文医药学期刊报道的精神药物相关死亡病例的数量、性别、年龄、药源性死亡原因分类、死亡与药物相关规律,探讨精神药物相关死亡的防治措施。结果:1978-2019年文献报道的精神药物应用相关的死亡有1729例,男女比例1.88∶1,年龄主要在40~69岁,其中猝死1218例(70.44%),噎食或窒息196例(11.34%),神经阻滞药恶性综合征85例(4.92%),肠梗阻53例(3.07%),白细胞减少或缺乏45例(2.60%),电解质紊乱29例(1.68%),过敏性休克7例(0.40%),剥脱性皮炎4例(0.23%),其他92例(5.23%,包括肝坏死、胰腺坏死、肺栓塞等)。使用人次最多的10种精神药物是氯丙嗪(339例)、氯氮平(312例)、氟哌啶醇(132例)、奋乃静(112例)、舒必利(87例)、碳酸锂(54例)、利培酮(29例)、氯硝西泮(19例)、丙戊酸钠(15例)、奥氮平(11例)。结论:应加强精神药物合理使用,密切监测和防治其严重药品不良反应。
Objective:To evaluate the characteristics and regularity of psychotropic drugs-related death cases reported in China,so as to provide reference for the prevention and treatment of serious adverse drug reactions induced by psychotropic drugs.Methods:The number,gender and age of clinical death cases related to psychotropic drugs reported in Chinese medical journals were analyzed by documentary method.The classification and regularity of drug-related causes of death,and the prevention and treatment of psychotropic drugs-related deaths were discussed.Results:There were totally 1729 deaths related to psychotropic drug use,with the sex ratio of 1.88∶1 and age range of 40-69 years.Of all the cases,1218 were sudden deaths(70.44%),196 were choking or asphyxia(11.34%),85 cases were neuroleptic malignant syndrome(4.92%),53 cases were intestinal obstruction(3.07%),45 cases were leukopenia or leukocyte deficiency(2.60%),29 cases were electrolyte disorder(1.68%),7 cases were allergic shock(0.40%)and 4 cases were exfoliative dermatitis(0.23%).Besides,there were 92 other cases(5.23%),including liver necrosis,pancreatic necrosis,pulmonary embolism,etc.The 10 most frequently-used psychotropic drugs were:chlorpromazine(339 cases),clozapine(312 cases),haloperidol(132 cases),perphenazine(112 cases),sulpiride(87 cases),lithium carbonate(54 cases),risperidone(29 cases),clonazepam(19 cases),sodium valproate(15 cases)and olanzapine(11 cases).Conclusion:Efforts should be made in rational use of psychotropic drugs and close monitoring and prevention of serious adverse drug reactions.
作者
王竞
周文犁
朱志先
周延安
WANG Jing;ZHOU Wenli;ZHU Zhixian;ZHOU Yan’an(Department of Clinical Psychology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Information Center,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Pharmacy,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《药学服务与研究》
CAS
2021年第5期351-354,共4页
Pharmaceutical Care and Research
关键词
精神药物
死亡病例
药物副反应报告系统
文献分析
psychotropic drugs
death case
adverse drug reaction reporting sysetem
literature analysis
