摘要
To the Editor:As the prevalence of stroke in the general population is two to three times less than among patients with type 2 diabetes mellitus(T2DM),among whom stroke accounts for 11.0%of all deaths,stroke is clearly a major macrovascular complication that increases the mortality and morbidity of patients with T2DM.[1]The pathophysiology of stroke consists of complicated processes involving oxidative stress,endothelial dysfunction,and pro-inflammatory response.CD36 is a B scavenger receptor that is involved in inflammation,innate immunity,and lipid metabolism and has been implicated in the pathophysiology of atherosclerosis.[2]However,there is no study evaluating the effect of CD36 polymorphism in patients with T2DM according to disease duration.Therefore,the present study evaluates the association between the rs1761667 CD36 single nucleotide polymorphism(SNP)and stroke in Korean patients with T2DM according to disease duration.
基金
supported by the Chungbuk National University College of Medicine.
