摘要
衰老始于生命早期阶段,是机体各器官功能随年龄增长出现普遍的、逐渐下降的不可逆过程。血管衰老作为机体衰老的一部分,在血管衰老相关疾病的发生发展中起重要作用。自噬通过降解受损、变性或衰老的蛋白质和细胞器来维持细胞内环境的稳态。研究发现,基础水平的自噬在调节正常血管功能方面发挥着重要作用,然而,异常自噬与血管衰老及其相关疾病的发生发展密切相关。本文旨在综述自噬在血管衰老相关疾病中的研究进展。
Aging begins in the early stages of life and is an irreversible process in which wide-ranging and gradual functional declines occur with age in various organs of the body.Vascular aging,as a part of the overall aging process,plays an important role in the occurrence and development of vascular senescence-related diseases.Autophagy maintains homeostasis of the intracellular environment via degradation of damaged,denatured,or senescent proteins and organelles.Studies have found that basal autophagy is critical in regulating normal vascular function.However,abnormal autophagy may contribute to vascular aging and diseases associated with it.The purpose of this paper is to review recent progress on autophagy in vascular aging and its related diseases.
作者
潘慧
刘化芳
王莉
王晓
Pan Hui;Liu Huafang;Wang Li;Wang Xiao(The Second Department of Geriatrics,Central Theater Command General Hospital of Chinese People's Liberation Army,Wuhan 430070,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2021年第10期1317-1322,共6页
Chinese Journal of Geriatrics
基金
中部战区总医院育英计划孵化项目(ZZYFH202113)。
关键词
血管衰老
自噬
衰老相关疾病
Vascular aging
Autophagy
Age-related diseases
