摘要
目的分析体检人群血压与血清肌酐及肾小球滤过率的相关性。方法本研究为横断面研究,连续选取2018年1—12月在新疆医科大学第一附属医院健康管理中心20岁以上资料相对完整的46792名体检人群为研究对象,通过现场问卷采集血压、肌酐等生理、生化指标,获取研究对象的基线数据。将研究对象按年龄分为20~64岁和≥65岁组,将血压指标按连续变量(收缩压、舒张压五分类)进行分析,采用F检验、t检验、χ^(2)检验和Logistic回归模型分析体检人群血清肌酐水平和肾小球滤过率的基线特征,以及血压与血清肌酐和肾小球滤过率的相关性。结果(1)20~93岁研究人群平均血清肌酐水平为(72.89±16.84)μmol/L,平均肾小球滤过率为(102.17±17.01)ml·min^(-1)·(1.73 m^(2))^(-1);男性平均血清肌酐水平高于女性,平均肾小球滤过率低于女性(均P<0.001)。(2)上述体检人群中血清肌酐水平异常者为514例(1.10%),肾小球滤过率异常者为657例(1.40%),男性、≥65岁人群、糖尿病、高血压者的血清肌酐水平和肾小球滤过率异常发生率更高(均P<0.05)。(3)肌酐水平和肾小球滤过率在性别、年龄、血压、体质指数方面的差异均有统计学意义(均P<0.05)。(4)随着血压的升高,20~64岁人群调整性别、年龄、民族、体质指数、高血压、糖尿病等变量后,血压≥180/110 mmHg(1 mmHg=0.133 kPa)组血清肌酐水平异常及肾小球滤过率异常的相对危险分别是血压<120/80 mmHg组的8.434、5.168倍;而≥65岁人群只有血压在160~179/100~109 mmHg组有统计学意义。结论20~64岁人群血压与血清肌酐及肾小球滤过率异常密切相关。
Objective To investigate and analyze the correlation between blood pressure and serum creatinine(Scr)and glomerular filtration rate(GFR).Methods This research was a cross-sectional study,a total of 46792 people over 20 years old with relatively complete data in the health management center of the First Affiliated Hospital of Xinjiang Medical University from January to December 2018 were included as the research subjects,and baseline data of these study subjects were obtained by on-site questionnaire,collection of blood pressure,creatinine and other physiological and biochemical indicators.The subjects were divided into 20-64 years old group and≥65 years group according to their age;being treated as the continuous variables(systolic blood pressure,diastolic blood pressure,five categories),their blood pressure indicators were analyzed.The F test,t test,χ2 test and logistic regression model were used to analyze the baseline characteristics of Scr level and GFR,as well as the correlation between blood pressure and Scr and GFR.Results(1)The average Scr level was(72.89±16.84)μmol/L in the study population aged 20-93.The average GFR was(102.17±17.01)ml·min^(-1)·(1.73 m^(2))^(-1).The average Scr of men was higher than that of women,the average GFR of men was lower than that of women(all P<0.001).(2)Among the subjects above,there were 514 cases(1.10%)with abnormal Scr level and 657 cases(1.40%)with abnormal GFR,the incidence of abnormal Scr and GFR was higher in men,subjects with age≥65 years old,or diabetes,or hypertension(all P<0.05).(3)There were significant differences in Scr level and GFR in subjects with different gender,age,blood pressure and body mass index(BMI)(all P<0.05).(4)With the increase of blood pressure,among the crowd of 24-64 years old,the relative risk of abnormal Scr and GFR in the group with baseline blood pressure≥180/110 mmHg was 8.434 and 5.168 times higher than that in the group with baseline blood pressure<120/80 mmHg,respectively,after adjusting variables such as sex,age,nationality
作者
李娜
吴建荣
杨晓萍
王淑霞
Li Na;Wu Jianrong;Yang Xiaoping;Wang Shuxia(Health Management Center,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《中华健康管理学杂志》
CAS
CSCD
2021年第5期479-484,共6页
Chinese Journal of Health Management
基金
新疆维吾尔自治区创新环境建设专项(PT2019)。
关键词
高血压
肌酐
肾小球滤过率
相关性
Hypertension
Creatinine
Glomerular filtration rate
Correlation
