摘要
采用开环聚合法制备了聚己内酯-聚乙二醇-聚己内酯(PCL-PEG-PCL)共聚物,再采用水包油包水(W_(1)/O/W_(2))复乳法制备载姜黄素PCL-PEG-PCL微球,研究载药微球释药行为。通过红外光谱(FT-IR)、热重分析仪、扫描电镜(SEM)等技术对其组成及结构进行表征。FT-IR结果表明PEG接枝上PCL;SEM结果表明微球形貌圆整;粒度分析表明粒径范围在6.3~10.3μm;热分析结果表明在30~60℃内微球存在相变过程;体外释药结果表明微球对药物具有缓释功能,释药机制以扩散为主,微球外部骨架溶蚀为辅。
PCL-PEG-PCL polymers were prepared by ring-opening polymerization.Curcumin-loaded PCL-PEGPCL microspheres were prepared by W_(1)/O/W_(2) double emulsion method.The drug release behavior of drug-loaded microspheres were studied.The composition of the copolymers were characterized by FT-IR,TGA,SME analysis technology.FT-IR results showed that the copolymers contained the segments of PCL and PEG.SEM confirmed that the structure of the microsphere were round.Particle size analysis showed that the particle size ranges from 6.3~10.3μm.The results of thermal analysis showed that it’s a phase transition process at 30~60℃.In vitro release results shown that PCL-PEG-PCL microspheres had sustained-release effect on Cur.The mechanism of drug release was mainly diffusion,supplemented by the dissolution of the external skeleton of the microspheres.
作者
蔡杰慧
卢金娟
郑燕菲
Cai Jiehui;Lu Jinjuan;Zheng Yanfei(College of Chemisty and Biological Engineering,Guangxi Normal University for Nationalities,Chongzuo 532200)
出处
《化工新型材料》
CAS
CSCD
北大核心
2021年第9期250-254,共5页
New Chemical Materials
基金
国家级大学生创新创业训练计划项目(201910604021)
广西教育厅2019年广西高校中青年教师基础能力提升项目(2019KY0763)
广西民族师范学院科研资助项目(2018YB033)。
