摘要
目的探究颠倒散石膏倒模配合美诺平颗粒治疗中重度痤疮的临床效果。方法选取2019年5月至2020年5月我院收治的100例中重度痤疮患者作为本研究对象,遵循数字随机法将其分为对照组(n=50)和研究组(n=50)。对照组开展颠倒散石膏倒模治疗,研究组开展颠倒散石膏倒模配合美诺平颗粒治疗。比较两组患者的治疗效果。结果研究组的治疗总有效率为84.00%,高于对照组的54.00%(P<0.05)。治疗后,研究组的TNF-α、hs-CRP、IL-17、IL-18水平低于对照组(P<0.05)。研究组的不良反应总发生率为2.00%,低于对照组的14.00%,差异具有统计学意义(P<0.05)。治疗后,研究组的睾酮水平低于对照组,雌二醇水平高于对照组(P<0.05)。治疗后,研究组的中医证候、SAS、SDS评分低于对照组(P<0.05)。结论颠倒散石膏倒模配合美诺平颗粒治疗中重度痤疮,对提升患者临床疗效、改善性激素、炎性因子水平、情绪状态以及减轻不良反应发生情况有显著作用。
Objective To explore the clinical effect of reverse loose plaster inverted mold combined with minopine granule in the treatment of moderate and severe acne.Methods A total of 100 patients with moderate and severe acne treated in our hospital from May 2019 to May 2020 were selected as the research objects.The patients were divided into control group(n=50)and study group(n=50)according to the digital random method.The control group was treated with reverse loose plaster inverted mold,and the study group was treated with reverse loose plaster inverted mold combined with minopine granules.The curative effect was compared between the two groups.Results The total effective rate of treatment in the study group was 84.00%,which was higher than 54.00% in the control group(P<0.05).After treatment,the levels of TNF-α,hs-CRP,IL-17 and IL-18 in the study group were lower than those in the control group(P<0.05).The total incidence of adverse reactions in the study group was 2.00%,which was lower than 14.00% in the control group,the difference was statistically significant(P<0.05).After treatment,the testosterone level of the study group was lower than that of the control group,and the estradiol level was higher than that of the control group(P<0.05).After treatment,the scores of TCM syndrome,SAS and SDS of the study group were lower than those of the control group(P<0.05).Conclusion Reverse loose plaster inverted mold combined with minopine granules in the treatment of moderate and severe acne has a significant effect on improving the clinical efficacy,and the levels of sex hormones and inflammatory factors,emotional state and reducing the occurrence of adverse reactions.
作者
王亚莎
陈卫卫
畅琳
WANG Yasha;CHEN Weiwei;CHANG Lin(Ankang Hospital of Traditional Chinese Medicine,Ankang 725000;Shaanxi Provincial Cancer Hospital,Xi'an 710061,China)
出处
《临床医学研究与实践》
2021年第30期122-124,共3页
Clinical Research and Practice
关键词
颠倒散石膏倒模
美诺平颗粒
中重度痤疮
炎症因子
性激素
reverse loose plaster inverted mold
minopine granules
moderate and severe acne
inflammatory factor
sex hormones
