摘要
目的:研究单孔胸腔镜辅助肺癌根治术对原发性肺癌患者疗效及半乳糖凝集素-3(galectin-3),三基序蛋白59 mRNA(TRIM59 mRNA)水平的影响。方法:选择2018年2月-2020年2月本院收治的原发性肺癌患者85例为研究对象,将其根据随机数字表法分为单孔组42例和三孔组43例。三孔组采用三孔胸腔镜辅助肺癌根治术治疗,单孔组采用单孔胸腔镜辅助肺癌根治术治疗。比较两组手术指标和手术前后血清galectin-3、TRIM59 mRNA及免疫功能指标水平,观察两组并发症发生情况。结果:单孔组术中出血量、术后引流量均少于三孔组,引流管留置时长、住院时长均短于三孔组,差异均有统计学意义(P<0.05)。两组手术时间比较,差异无统计学意义(P>0.05)。术后7 d,单孔组血清galectin-3、TRIM59 mRNA水平均低于三孔组,差异均有统计学意义(P<0.05)。单孔组术后并发症总发生率低于三孔组,差异有统计学意义(P<0.05)。术后7 d,单孔组血清IgA、IgG、IgM水平均高于三孔组,差异均有统计学意义(P<0.05)。结论:单孔胸腔镜辅助肺癌根治术治疗原发性肺癌患者的效果显著,可有效降低galectin-3及TRIM59 mRNA表达水平,同时减轻对免疫功能的影响,降低术后并发症发生率。
Objective:To study the effect of single-hole thoracoscopic assisted radical resection of lung cancer patients and the effects of galectin-3 and TRIM59 mRNA levels.Method:A total of 85 patients with primary lung cancer admitted to our hospital from February 2018 to February 2020 were selected as the study subjects,and they were divided into single-hole group(n=42)and three-hole group(n=43)according to random number table method.The three-hole group was treated with three-hole thoracoscopy assisted radical resection of lung cancer,while the single-hole group was treated with single-hole thoracoscopy assisted radical resection of lung cancer.The levels of serum galectin-3,TRIM59 mRNA and immune function indexes before and after operation were compared between the two groups,and the incidence of complications between the two groups were observed.Result:The intraoperative bleeding and postoperative drainage volume in the single-hole group were less than those in the three-hole group,and the indwelling time and hospitalization time of the drainage tube were shorter than those in the three hole-group,the differences were statistically significant(P<0.05).Comparison of operation time between the two groups,there was no significant difference(P>0.05).7 d after operation,the serum galectin-3 and TRIM59 mRNA levels in the single-hole group were lower than those in the three-hole group,the differences were statistically significant(P<0.05).The total incidence of postoperative complications in the single-hole group was lower than that in the three-hole group,the difference was statistically significant(P<0.05).7 d after operation,the levels of serum IgA,IgG and IgM in the single-hole group were higher than those in the three-hole group,the differences were statistically significant(P<0.05).Conclusion:Single-hole thoracoscopic assisted radical resection of lung cancer is effective in the treatment of patients with primary lung cancer.It can effectively reduce the expression levels of galectin-3 and TRIM59 mRNA,reduce the impac
作者
赵钰
ZHAO Yu(Tieling Central Hospital,Tieling 112000,China)
出处
《中国医学创新》
CAS
2021年第27期1-4,共4页
Medical Innovation of China
