摘要
目的分析糖皮质激素联合特布他林治疗慢性阻塞性肺疾病(慢阻肺)急性加重期的临床效果。方法68例慢阻肺急性加重期患者,随机分为对照组和观察组,每组34例。对照组给予特布他林治疗,观察组给予糖皮质激素联合特布他林治疗。对比两组临床疗效、治疗前后血气指标、治疗前后肺功能、不良反应发生情况。结果观察组临床总有效率为97.06%,高于对照组的79.41%,差异有统计学意义(P<0.05)。对照组治疗后,动脉血氧分压(PaO_(2))(72.12±7.43)mm Hg(1 mm Hg=0.133 kPa),动脉血二氧化碳分压(PaCO_(2))(57.11±5.73)mm Hg,血氧饱和度(SpO_(2))(95.14±1.87)%。观察组治疗后,PaO_(2)(85.18±6.82)mm Hg,PaCO_(2)(48.90±5.34)mm Hg,SpO_(2)(99.14±2.03)%。治疗后,观察组PaO_(2)、SpO_(2)均高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组第1秒用力呼气容积占预计值百分比(FEV1%)、用力肺活量占预计值百分比(FVC%)、最大呼气流量占预计值百分比(PEF%)均高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论糖皮质激素与特布他林联合治疗慢阻肺急性加重期患者,可快速改善患者动脉血气状态,促进肺功能恢复,值得广泛推广应用。
Objective To analyze the clinical effect of glucocorticoids combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods A total of 68 patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into control group and observation group,with 34 cases in each group.The control group was treated with terbutaline,and the observation group was treated with glucocorticoid and terbutaline.Both groups were compared in terms of clinical efficacy,blood gas indicators before and after treatment,lung function before and after treatment,and occurrence of adverse reactions.Results The total clinical effective rate of the observation group was 97.06%,which was higher than 79.41%of the control group,and the difference was statistically significant(P<0.05).After treatment,the arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))and blood oxygen saturation were(72.12±7.43)mm Hg(1 mm Hg=0.133 kPa),(57.11±5.73)mm Hg and(95.14±1.87)%in the control group,which were(85.18±6.82)mm Hg,(48.90±5.34)mm Hg and(99.14±2.03)%in the observation group.After treatment,PaO_(2) and SpO_(2) of the observation group were higher than those of the control group,and PaCO_(2) was lower than that of the control group.All the differences were statistically significant(P<0.05).After treatment,the forced expiratory volume in the 1st second as a percentage of the predicted value(FEV1%),forced vital capacity as a percentage of the predicted value(FVC%),and peak expiratory flow as a percentage of the predicted value(PEF%)of the observation group were all higher than those of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of glucocorticoids and terbutaline for patients with acute exacerbation of chronic obstructive pulmo
作者
常利
CHANG Li(People’s Hospital of Panshan County,Panjin 124100,China)
出处
《中国实用医药》
2021年第29期123-125,共3页
China Practical Medicine
关键词
糖皮质激素
特布他林
慢性阻塞性肺疾病
急性加重期
Glucocorticoids
Terbutaline
Chronic obstructive pulmonary disease
Acute exacerbation
