摘要
目的:比较炎症指标C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)、降钙素原(PCT)对克罗恩病(CD)患者的临床诊断、内镜活动性、临床活动性预测价值。方法:回顾性分析CD患者76例(CD组)和健康体检人群36例(对照组),收集所有CD患者CRP、SAA、PCT、CD简化内镜评分(SES-CD)、CD活动指数(CDAI)等检测结果,比较对照组、CD组炎症指标结果差异,通过受试者工作曲线(ROC)确定不同炎症指标对CD诊断、内镜下活动性、临床活动性预测价值,分析不同炎症指标与SES-CD、CDAI相关性,比较不同临床严重程度的CD患者炎症指标的差异。结果:CD组炎症指标均高于对照组,差异有统计学意义(P<0.05),CRP、SAA、PCT对CD预测AUC分别为0.728、0.824、0.636,CRP、SAA、PCT预测CD内镜下活动性AUC分别为0.739、0.805、0.608,CRP、SAA、PCT预测临床活动性AUC分别为0.731、0.808、0.605,CRP、SAA、PCT与SES-CD相关系数(r)值分别为0.442、0.676、0.314,与CDAIr值分别为0.459、0.621、0.289(P<0.05)。结论:CRP、SAA、PCT对CD诊断均有较好预测价值,CRP、SAA对内镜活动性、临床活动性预测价值较高,预测价值SAA>CRP>PCT。
Objective:To compare the predictive value of C-reactive protein(CRP),serum amyloid A(SAA)and procalcitonin(PCT)in the clinical diagnosis,endoscopic activity and clinical activity of Crohn’s disease(CD).Methods:A retrospective analysis of 76 CD patients and 36 healthy people who came to our hospital for medical examination was done.The results of CRP,SAA,PCT,Crohn’s disease simplified endoscopy score(SES-CD),crohn’s disease activity index(CDAI)and other tests of all CD patients were collected,and the results of infection index between the control group and the CD group were compared.The predictive value of different infection indexes for CD diagnosis,endoscopic activity,and clinical activity was determined through receiver operating curve(ROC),the correlation between different infection indexes and SES-CD and CDAI was analyzed,and the differences of CD infection indexes of different clinical severity were compared.Results:The infection indexes of the CD group were higher than those of the control group,and the difference was statistically significant(P<0.05).The predicted AUC of CRP,SAA and PCT on CD were 0.728,0.824 and 0.636,respectively.The AUC of CRP,SAA and PCT on predicted CD endoscopic mobility were 0.739,0.805 and 0.608,respectively.The AUC of CRP,SAA and PCT on predicted clinical activity were 0.731,0.808 and 0.605,respectively.The correlation coefficient(r)values of CRP,SAA,PCT and SES-CD were 0.442,0.676 and 0.314,respectively.The correlation coefficient values of CRP,SAA,PCT and CDAI were 0.459,0.621 and 0.289,respectively(P<0.05).Conclusion:CRP,SAA and PCT may have good predictive value for the diagnosis of CD,CRP and SAA may have higher predictive value for endoscopic activity and clinical activity,and the predictive value is SAA>CRP>PCT.
作者
杨芸
王亚红
何龙
姚丽君
杨东
YANG Yun;WANG Yahong;HE Long;YAO Lijun;YANG Dong(Department of Laboratory,921 Hospital,Joint Logistics Support Force,Changsha,410003,China)
出处
《临床血液学杂志》
CAS
2021年第8期556-560,共5页
Journal of Clinical Hematology
