摘要
嘌呤能信号对膀胱的功能有着重要的调节作用,嘌呤能信号的异常生成、释放和(或)嘌呤能受体的异常表达,导致的嘌呤能信号通路过度激活是许多泌尿疾病的共同特征。目前药物治疗在下尿路症状的治疗中多集中在对储尿期逼尿肌活动的调控,在储尿期感觉传入过敏的症状上存在一定局限性。随着对嘌呤能信号通路研究的深入,发现嘌呤能信号广泛分布于膀胱中,不仅涉及排尿期膀胱传出神经对逼尿肌的调节,还参与储尿期膀胱传入神经对感受刺激的调节,在改善下尿路症状方面更具优势,具有良好的临床应用前景,本文将对嘌呤能信号在膀胱的作用及相关疾病的研究进展进行综述,以期为后续研究提供参考。
Purinergic signaling plays an important role in the regulation of bladder function.Abnormal generation and release of purinergic signaling and/or abnormal expression of purinergic receptors are common characteristics of many urinary diseases.At present,drug therapy in the treatment of LUTS mostly focuses on the regulation of detrusor activity in the urine storage stage,and there are some limitations in the symptoms of sensory afferent overactivation in the urine storage stage.With the deepening of the research of purinergic signal pathway,purinergic signaling is widely distributed in the bladder,not only involves the urination period bladder detrusor regulation by efferent nerve,also participates in the urine storage period,the regulation of bladder afferent nerve to feel stimulation.More advantages in improving of lower urinary tract symptoms are found,so a good prospect of clinical application is shown.This paper will summarize the research progress of the purinergic signaling in bladder and related disease so as to provide reference for further research.
作者
李之豪
刘建党
冯戟玮
李雯
赵雪丹
胡俊威
陈跃来
LI Zhihao;LIU Jiandang;FENG Jiwei;LI Wen;ZHAO Xuedan;HU Junwei;CHEN Yuelai(Shanghai University of Traditional Chinese Medicine,Shanghai,201203,China)
出处
《临床泌尿外科杂志》
CAS
2021年第9期754-758,共5页
Journal of Clinical Urology
关键词
嘌呤能信号
嘌呤能受体
三磷酸腺苷
膀胱功能
下尿路症状
purinergic signaling
purinergic receptor
adenosine-triphosphate
bladder function
lower urinary tract symptom
