摘要
开发了一种以芳基甲基酮或脂肪酮和2-氨基苯硫酚为原料,正丁醇为溶剂,120℃条件下经Selectfluor氧化合成2-取代苯并噻唑类衍生物的方法.通过改变底物芳基甲基酮上的取代基可以获得具有生物活性的药物中间体.
2-Arylbenzothiazoles were effectively synthesized via an oxidative process by Selectfluor in 1-butanol at 120℃,using 2-arylbenzothiazoles and aryl/aliphatic ketones as starting materials.Bioactive pharmaceutical intermediates were obtained by selecting substituents on the ring of aryl methyl ketones.
作者
傅琴姣
张瑞芹
裘浣沂
马仁超
马永敏
Fu Qinjiao;Zhang Ruiqin;Qiu Huanyi;Ma Renchao;Ma Yongmin(School of Pharmaceutical and Chemical Engineering,Taizhou University,Taizhou,Zhejiang 318000)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2021年第9期3585-3592,共8页
Chinese Journal of Organic Chemistry
基金
浙江省领军型创新团队(No.2019R01005)资助项目.
