摘要
为了探究右美托咪定复合强痛宁对犬的麻醉效果,试验选取健康杂种犬6只,体重10~15 kg,实施颈部肌肉注射右美托咪定(按体重80μg/kg)和强痛宁(按体重0.1 mg/kg)。6只试验犬作为麻醉组先进行单纯麻醉试验。14 d后再次对这6只犬麻醉并进行手术试验,作为手术组,剖腹探查术2只、节育术4只(其中公犬去势术和母犬绝育术各2只)。试验犬术前不断水,禁食6~8 h,手术部位提前进行剃毛消毒。在复合麻醉前和注射药物后5,10,20,30,40,50,60 min监测体温、心率、血氧饱和度、血压(收缩压、舒张压、平均动脉压)以及反射活动(角膜、肛门、眼睑反射),并比较单纯麻醉和麻醉后手术过程中具体的麻醉效果。结果表明:试验犬注射右美托咪定和强痛宁后,平均在4.1 min内进入麻醉期,麻醉持续时间比较适宜,麻醉组苏醒期为(45.00±6.11)min,手术组苏醒期为(43.25±3.14)min,手术组与麻醉组的体温变化基本相同,随着麻醉时间延长,呈现出逐渐下降的趋势,两组间体温在麻醉后5~15 min内差异显著(P<0.05),但之后均差异不显著(P>0.05)。相同时间点手术组和麻醉组犬的血氧饱和度无显著差异(P>0.05),呈先下降后逐渐升高趋势,两组的血氧饱和度最低在80%左右,氧合状态略差,而麻醉后10~35 min手术组血氧饱和度较麻醉组略低。麻醉后20~60 min手术组的心率显著高于麻醉组(P<0.05)。麻醉后5~55 min手术组与麻醉组的收缩压、舒张压、平均动脉压均差异不显著(P>0.05),手术组均为先下降后平稳回升,在麻醉组中出现平缓下降趋势;麻醉后60 min,手术组与麻醉组的收缩压、舒张压、平均动脉压均差异显著(P<0.05)。试验犬在手术期间角膜、肛门反射均未完全消失,麻醉组试验犬在注射麻醉剂的20~60 min内肛门、角膜反射表现出反应迟钝,而在15~60 min时间内,眼睑反射无反应。说明犬颈部肌肉注射右美托咪定和强痛宁,可顺利完成
In order to explore the anesthesia effect of dexmedetomidine combined with Qiangtongning on dogs,the experiment selected 6 healthy mongrel dogs,weighing 10-15 kg,and administered dexmedetomidine(according to the weight of 80μg/kg)and Qiangtongning(according to the weight of 0.1 mg/kg)intramuscularly to the neck.Six test dogs were treated as anesthesia group for simple anesthesia test first.14 days later,the 6 dogs were anesthetized again and the operation test was performed.As the operation group,there were 2 for laparotomy,and 4 for birth control including 2 male dogs and 2 female dogs.Before the operation,the test dogs should be kept hydrated;fasting for 6-8 hours;and the surgical site should be shaved and disinfected in advance.Before compound anesthesia and 5,10,20,30,40,50,60 min post administration,body temperature,heart rate,blood oxygen saturation,blood pressure(systolic blood pressure,diastolic blood pressure,mean arterial pressure)and other physiological indicators and reflex activities(cornea,anus,eyelid reflex)and other elements were monitored;the specific anesthesia effect was compared between simple anesthesia and post-anesthesia surgery.The results show that after injection of dexmedetomidine and Qiangtongning,the dogs entered the anesthesia period within 4.1 min on average,and the duration of anesthesia was relatively suitable.The recovery period of the anesthesia group was(45.00±6.11)min,and that of the operation group was(43.25±3.14)min.The changes of body temperature in the operation group and the anesthesia group were basically the same.There was a significant difference in body temperature between the two groups within 5-15 min after anesthesia(P<0.05),but there was no significant difference after anesthesia(P>0.05).At the same time point,there was no significant difference in the blood oxygen saturation between the operation group and the anesthesia group(P>0.05),which decreased at first and then gradually increased.The lowest blood oxygen saturation of the two groups was about 80%,and th
作者
申美伦
连慧敏
张志恒
马相影
李柔茜
金箫迪
高利
SHEN Meilun;LIAN Huimin;ZHANG Zhiheng;MA Xiangying;LI Rouqian;JIN Xiaodi;GAO Li(Heilongjiang Key Laboratory for Experimental Animals and Comparative Medicine,College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China)
出处
《黑龙江畜牧兽医》
CAS
北大核心
2021年第18期124-129,共6页
Heilongjiang Animal Science And veterinary Medicine
基金
国家自然科学基金项目(31572580,31372491)
黑龙江省应用技术研究与开发计划重大项目(GA18B203)
“十三五”重大专项省级资助项目(GX18B023)。
关键词
犬
复合麻醉
肌肉注射
手术验证
右美托咪定
强痛宁
dog
compound anesthesia
intramuscular injection
surgical verification
dexmedetomidine
Qiangtongning
