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Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization

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摘要 Dear Editor,Lung cancer is the most common cause of cancer-related mortality worldwide,with non-small cell lung cancer(NSCLC)accounting for the largest number of cases.1 Ionizing radiation(IR)is widely used as an indispensable tool for treating lung cancer patients;however,the acquisition of resistance following radiation is the major obstacle for reducing the efficacy of radiotherapy.
出处 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2021年第8期2311-2314,共4页 信号转导与靶向治疗(英文)
基金 This research was supported by the Bio and Medical Technology Development Program of the National Research Foundation(NRF) grant of the Korea Institute of Radiological and Medical Sciences(KIRAMS)funded by the Korean government(MSIT,2019M3E5D1A01069361,2019R1A2C2087551,and 50535-2020).
关键词 LUNG cancer MORTALITY
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