摘要
目的探讨解毒泄浊益肾汤联合苯溴马隆对痛风性关节炎病人血清3-硝基酪氨酸(3-NT)水平、Lysholm评分及疼痛数字评价量表(NRS)评分的影响。方法回顾性分析2016年4月至2018年4月武汉市第五医院80例痛风性关节炎门诊病人临床资料。依据治疗方法不同分为对照组40例和观察组40例。治疗前,两组病人均进行低嘌呤饮食,大量饮水,使尿量维持在2000~3000 mL/d。对照组给予苯溴马隆治疗,观察组在对照组基础上给予解毒泄浊益肾汤治疗。通过酶联免疫吸附法(ELISA)测量血清8-羟基脱氧鸟苷(8-OHdG)、3-NT水平、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白细胞介素-1β(IL1β)、肿瘤坏死因子-α(TNF-α)水平;通过全自动生化分析仪尿酸酶测定血清尿酸(BUA)水平;通过Lysholm系统评估治疗前后膝关节功能;通过NRS评估治疗前后膝关节疼痛程度,并观察不良反应发生情况。结果治疗后,观察组治疗总有效率为97.50%,对照组为80.00%,经秩和检验,差异无统计学意义(P>0.05)。治疗前,两组血清8-OHdG、3-NT、BUA、IL-6、IL-10、IL1β、TNF-α、Lysholm、NRS比较,差异无统计学意义(P>0.05)。治疗后,观察组和对照组血清8-OHdG、3-NT、BUA、IL-6、IL-10、IL-1β、TNF-α、NRS均低于治疗前,观察组低于对照组(P<0.05);治疗后Lysholm评分,观察组[(95.68±26.68)分比(44.39±17.93)分]和对照组[(83.54±23.37)分比(44.28±17.85)分]高于治疗前,观察组高于对照组(P<0.05);观察组与对照组不良反应发生率比较差异无统计学意义(P>0.05)。结论解毒泄浊益肾汤联合苯溴马隆能有效改善氧化应激反应状态,降低血尿酸水平,抑制炎症反应发生,并有效缓解膝关节疼痛程度,恢复膝关节功能,具有一定推广价值。
Objective To explore the effects of Jiedu Xiezhuo Yishen decoction combined with benzbromarone on serum 3-nitrotyro‐sine(3-NT),Lysholm score and numerical rating scale(NRS)score in patients with gouty arthritis.Methods The clinical data of 80 outpatients with gouty arthritis treated in The Fifth Hospital in Wuhan from April 2016 to April 2018 were retrospectively analyzed.They were assigned into control group(40 cases)and experimental group(40 cases)according to different treatment methods.Before treatment,both groups were fed a low purine diet and drank plenty of water to maintain urine volume between 2000-3000 mL/d.The control group was treated with benzbromarone,while the experimental group was treated with Jiedu Xiezhuo Yishen decoction on the ba‐sis of the control group.The levels of serum 8-hydroxydeoxyguanosine(8-OHdG),3-NT,interleukin-6(IL-6),interleukin-10(IL-10),in‐terleukin-1β(IL-1β)and tumor necrosis factor(TNF-α)were measured by enzyme-linked immunosorbent assay(ELISA),the level of se‐rum uric acid(BUA)was measured by uricase-free biochemical analyzer,knee function was assessed by Lysholm system before and af‐ter treatment;and knee pain was assessed by NRS before and after treatment,the adverse reactions were observed.Results After treat‐ment,the total effective rate of gouty arthritis patients in the experimental group was 97.50%,and that in the control group was 80.00%,the difference was not statistically significant by rank sum test(P>0.05).Before treatment,there was no significant difference in serum 8-OHdG,3-NT,BUA,IL-6,IL-10,IL-1β,TNF-α,Lysholm and NRS between the two groups(P>0.05).After treatment,the serum 8-OHdG,3-NT,BUA,IL-6,IL-10,IL-1β,TNF-α,NRS of gouty arthritis patients in the experimental group and the control group were lower than those before treatment,and these indexes in the experimental group were lower than those in the control group(P<0.05);the Lysholm scores of gouty arthritis patients in the experimental group[(95.68±26.68)vs.(44.39±17.93)]and the control
作者
何玲
丁明桥
雷慧敏
焦群茹
祝丹妮
李娅
HE Ling;DING Mingqiao;LEI Huimin;JIAO Qunru;ZHU Danni;LI Ya(Department of Rehabilitation,The Fifth Hospital in Wuhan,Wuhan,Hubei 430050,China)
出处
《安徽医药》
CAS
2021年第11期2294-2297,共4页
Anhui Medical and Pharmaceutical Journal
基金
武汉市卫生和计划生育委员会中医药一般项目(WZ16C24)。
