摘要
目的:探讨基于磁共振血管成像的结核性脑膜炎(TBM)颅内动脉损害的影像表现与宿主免疫状态的关系。方法:选取2018年7月~2020年3月我院收治的结核性脑膜炎患者121例,依据检查结果分为重度狭窄组(19例)、中度狭窄组(35例)、轻度狭窄组(31例)和无狭窄组(36例)。采用流式细胞仪检测各组Th1、Th2、Th17、Treg细胞及血清T细胞亚群(CD4+、CD8+)水平。结果:较中度、轻度和正常组,重度狭窄组CD4+、Th1、Th2和Th17明显更高,而Treg和CD8+明显更低(P<0.05);TBM患者颅内动脉狭窄程度与高血脂、糖尿病、高血压、CD4+、Th1、Th2和Th17呈显著正相关(P<0.05)。结论:结核性脑膜炎患者存在不同程度免疫功能缺失,其表达可作为评估颅内段狭窄的可靠指标。
Objective:To explore the relationship between the imaging manifestation of intracranial artery damage and host immune state in tuberculous meningitis(TBM)based on magnetic resonance angiography.Methods:121 patients with tuberculous meningitis admitted to our hospital from July 2018 to March 2020 were divided into severe stenosis group(19 cases),moderate stenosis group(35 cases),mild stenosis group(31 cases)and no stenosis group(36 cases).The levels of Th1,Th2,Th17,Treg cells and serum T cell subsets(CD4+,CD8+)were measured by flow cytometry.Results:Compared with moderate,mild and normal groups,CD4+,Th1,Th2 and Th17 in severe stenosis group were significantly higher,while Treg and CD8+were significantly lower(P<0.05).The degree of intracranial artery stenosis in TBM patients was positively correlated with hyperlipidemia,diabetes,hypertension,CD4+,Th1,Th2 and Th17(P<0.05).Conclusion:Patients with tuberculous meningitis have different degrees of immune function loss,and its expression can be used as a reliable index to evaluate intracranial stenosis.
作者
余利生
Yu Lisheng(Department of Neurology,Yuedong Hospital,Third Affiliated Hospital of Sun Yat-sen University,Meizhou,Guangdong 514000)
出处
《现代医用影像学》
2021年第8期1391-1394,共4页
Modern Medical Imageology
基金
广东省医学科学技术研究基金项目,项目编号:201811515580203。
关键词
磁共振血管成像
结核性脑膜炎
颅内动脉损害
影像表现
免疫状态
T细胞亚群
magnetic resonance angiography
tuberculous meningitis
intracranial artery damage
the immune status
T cell subsets
pearson related
