摘要
目的探讨支气管镜下肺泡灌洗结合双水平正压通气治疗慢性阻塞性肺疾病急性加重期(AECOPD)伴Ⅱ型呼吸衰竭的效果。方法选取2018年10月至2020年10月收治的60例AECOPD伴Ⅱ型呼吸衰竭患者,根据抽签法将其随机分为对照组与观察组,各30例。对照组采用常规治疗+双水平正压通气,观察组在对照组的基础上结合支气管镜下肺泡灌洗。比较两组的治疗效果、血气分析指标、HMGB1、α-HBDH、β-EP水平。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的PaO2、pH高于对照组,PaCO2低于对照组(P<0.05)。治疗后,观察组的HMGB1、α-HBDH、β-EP水平均低于对照组(P<0.05)。结论支气管镜下肺泡灌洗结合双水平正压通气治疗AECOPD伴Ⅱ型呼吸衰竭的效果显著,可促进血气分析指标改善,降低HMGB1、α-HBDH、β-EP水平,值得推广。
Objective To explore the effect of bronchoscopy alveolar lavage combined with bilevel positive pressure ventilation in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and type Ⅱ respiratory failure.Methods A total of 60 patients with AECOPD and type Ⅱ respiratory failure treated from October 2018 to October 2020 were selected and randomly divided into control group and observation group according to drawing lots,with 30 cases in each group.The control group was treated with routine treatment+bilevel positive pressure ventilation,and the observation group was combined with bronchoscopy alveolar lavage on the basis of the control group.The therapeutic effect,blood gas analysis indexes,HMGB1,α-HBDH,β-EP levels of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,PaO2 and pH in the observation group were higher than those in the control group,and PaCO2 was lower than that in the control group(P<0.05).After treatment,HMGB1,α-HBDH,β-EP levels in the observation group were lower than those in the control group(P<0.05).Conclusion Bronchoscopy alveolar lavage combined with bilevel positive pressure ventilation in the treatment of AECOPD and typeⅡrespiratory failure has significant effect,it can promote the improvement of blood gas analysis indexes and reduce HMGB1,α-HBDH,β-EP levels,which is worthy of promotion.
作者
何小勇
宋海刚
HE Xiaoyong;SONG Haigang(Xi'an Metallurgical Hospital,Xi'an 710000;Xianyang Hospital of Yan'an University,Xianyang 712000,China)
出处
《临床医学研究与实践》
2021年第29期65-67,共3页
Clinical Research and Practice
关键词
支气管镜下肺泡灌洗
双水平正压通气
慢性阻塞性肺疾病急性加重期
Ⅱ型呼吸衰竭
bronchoscopy alveolar lavage
bilevel positive pressure ventilation
acute exacerbation of chronic obstructive pulmonary disease
typeⅡrespiratory failure
