摘要
社区获得性呼吸窘迫综合征(CARDS)毒素是近年来发现的肺炎支原体唯一的毒力因子,在肺炎支原体的致病过程中发挥重要作用。及时掌握CARDS毒素的作用机制,有助于深入理解肺炎支原体感染的致病特点,为治疗和预后评估提供参考。检测临床样本中是否存在CARDS毒素并监测其浓度变化,为临床肺炎支原体感染的诊断和治疗评估提供了新的方向。本文就肺炎支原体CARDS毒素的发现、致病机制、检测方法及临床价值作一简要综述。
Community acquired respiratory distress syndrome(CARDS)toxin is the only virulence factor of Mycoplasma pneumoniae found in recent years,which plays an important role in the pathogenic process of Mycoplasma pneumoniae.Timely understanding the mechanism of CARDS toxin is helpful to elucidate the pathophysiology of Mycoplasma pneumoniae infection and provide reference for treatment and prognosis evaluation.Detection of CARDS toxin in clinical samples and monitoring of its concentration changes provide a new direction for the diagnosis and treatment evaluation of Mycoplasma pneumoniae infection.This article briefly reviews the discovery,pathogenic mechanism,detection methods and clinical value of Mycoplasma pneumoniae CARDS toxin.
作者
方云
柏长青
牛文凯
苑鑫
Fang Yun;Bai Changqing;Niu Wenkai;Yuan Xin(Department of Respiratory and Critical Care Diseases,Senior Department of Infectious Diseases,the Fifth Medical Center of PLA General Hospital,Beijing 100071,China)
出处
《国际呼吸杂志》
2021年第18期1424-1427,共4页
International Journal of Respiration
基金
国家自然科学基金(81400009)
首都临床特色应用研究(Z141107002514182)
青年培育拔尖项目(20QNPY115)。
关键词
社区获得性呼吸窘迫综合征毒素
支原体
肺炎
致病机制
研究进展
Community acquired respiratory distress syndrome toxin
Mycoplasma pneumoniae
Pathogenic mechanism
Research progress
