摘要
目的比较不同浓度平阳霉素对肝血管瘤的疗效。方法前瞻性选取2018年9月至2019年12月间大庆油田总医院门诊就诊血管瘤患者80例(瘤体80枚),按照随机数字表法分为4组,每组20例(20枚)。平阳霉素浓度分别为:1.6、0.8、0.6、0.4 mg/mL。于术后1、3、6、12个月随访瘤体大小,计算体积缩小率。术后1个月复查肾功能、肝功能+胆红素,术后6、12个月复查胸片。如有术中及术后并发症,记录其改善情况。结果术后12个月,1.6、0.8、0.6、0.4 mg/mL组瘤体缩小率分别为(93.65±4.81)%、(92.51±5.43)%、(95.65±2.20)%、(93.21±4.01)%,4组间差异无统计学意义(P>0.05)。1.6、0.8、0.6、0.4 mg/mL组平均治疗次数分别为:(1.20±0.42)、(2.10±0.57)、(3.30±0.68)、(4.60±0.70)次,4组间比较,差异有统计学意义(P<0.05)。80例患者,术后出现发热9例(11.25%),肝区疼痛16例(20.00%),一过性肝功能异常13例(16.25%),过敏性休克1例(1.25%)。各浓度组间发热、肝区疼痛及肝功能异常发生率比较,差异有统计学意义(P<0.05),浓度越大,术后不良反应发生率越高;4组间过敏性休克发生率比较,差异无统计学意义(P>0.05)。结论不同浓度平阳霉素治疗肝血管瘤疗效可靠。浓度越高,治疗次数越少。建议较大血管瘤(> 8 cm),采用低浓度多次治疗;较小血管瘤采用较高浓度治疗,可以减少治疗次数。
Objective To compare the therapeutic effects of different concentration pingyangmycin injection for treatment of hepatic hemangioma. Methods Eighty cases(80 tumors) of hepatic hemangioma were collected from Daqing Oilfield General Hospital during September 2018 to December 2019. All patients were separated into 4 groups according to the concentrations of pingyangmycin(1. 6,0. 8,0. 6 and 0. 4 mg/mL),each group 20 cases(20 tumors). The reduction rates were calculated at the follow-up of 1,3,6 and 12 months after operation. Renal function,liver function and bilirubin were reexamined 1 month after operation,and chest X-ray was reexamined 6 months and 12 months after operation.The intraoperative and postoperative complications were recorded and the improvement was observed. Results At 12 months postoperatively,the tumor reduction rates in the 1. 6,0. 8,0. 6,and 0. 4 mg/mL groups were(93. 65 ± 4. 81) %,(92. 51 ± 5. 43) %,(95. 65 ± 2. 20) %,(93. 21± 4. 01) %,respectively,there was no statistically significant difference between the 4 groups(P>0.05). The average treatment times in the1. 6,0. 8,0. 6,and 0. 4 mg/mL groups were:(1. 20 ± 0. 42),(2. 10 ± 0. 57),(3. 30 ± 0. 68),(4. 60 ± 0. 70) times,the difference was statistically significant between the 4 groups(P<0.05). Among the 80 patients,9(11. 25%) had postoperative fever,16(20. 00%) had liver pain,13(16. 25%) had abnormal liver function,and 1(1. 25%) had anaphylactic shock. There was significant difference in the incidence of fever,liver pain and abnormal liver function among different concentrations(P<0.05),there was no significant difference in the incidence of anaphylactic shock between the groups(P>0.05). Conclusion Different concentration Pingyangmycin injection for treatment of hepatic hemangioma are reliable. The higher concentration,the less treatment. It is suggested that the larger hemangioma was treated with low concentration,and the small hemangioma was treated with high concentration.
作者
闫妍
钱林学
袁莉
孙伟
YAN Yan;QIAN Lin-xue;YUAN Li(Department of Ultrasound,Daqing Oilfield General Hospital,Daqing Heilongjiang 163000,China;Department of Ultrasound,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)
出处
《临床和实验医学杂志》
2021年第16期1776-1779,共4页
Journal of Clinical and Experimental Medicine
基金
黑龙江省卫计委科学技术成果(编号:9232017Y617)。
关键词
肝血管瘤
超声引导
平阳霉素
浓度
Ultrasound-guided
Pingyangmycin
Hepatic hemangioma
Concentration
