摘要
母源-合子转换(Maternal-to-Zygotic Transition,MZT)是早期胚胎发育过程中母体产物到新生合子基因组发育控制的关键,包括母体成分(mRNAs和蛋白质)降解和合子基因组激活(Zygotic Genome Activation,ZGA)。虽然这两个阶段的基因调控模式不同,但在MZT中这些变化精确控制和高度关联。本文综述了ZGA过程中细胞周期、染色质和转录因子调控胚胎基因表达的特定模式,以及ZGA翻译后调控的变化,阐明了ZGA在MZT过程中的分子调控机制,为进一步研究MZT中基因表达的大规模变化提供理论基础。
The maternal-to-zygotic transition(MZT) is essential for the developmental control handed from maternal products to newly synthesized zygotic genome in the earliest stages of embryogenesis, including maternal component(mRNAs and proteins) degradation and zygotic genome activation(ZGA). Although the modes of gene regulation in these two stages are implemented, these changes in MZT of embryos are precisely controlled and highly interconnected. This paper summarizes the regulation of the cell cycle, chromatin and transcription factors together elicits specific patterns of embryonic gene expression at the MZT in animals, as well as changes in post-translational regulation of ZGA, and focuses on the molecular mechanisms of ZGA in the MZT, which provided a theoretical basis for further study of large-scale changes in gene expression during the MZT.
作者
赵向远
许保增
ZHAO Xiangyuan;XU Baozeng(Institute of Special Animal and Plant Sciences,Chinese Academy of Agricultural Science,Jilin Changchun 130112,China;Stake Key Laboratory for Molecular Biology of Special Economic Animal and Plant Science,Chinese Academy of Agricultural Science,Jilin Changchun 130112,China)
出处
《中国畜牧杂志》
CAS
北大核心
2021年第10期52-58,共7页
Chinese Journal of Animal Science
基金
国家自然科学基金面上项目(31772606)
吉林省自然科学基金(20190201170JC)
吉林省实验动物领域创新研究项目
中国农业科学院创新工程(CAAS-ASTIP-2020-ISAPS)。
关键词
合子基因组激活
细胞周期
染色质开放性
转录因子
翻译后调控
Zygotic genome activation
Cell cycle
Chromatin
Transcription factors
Post-translational regulation
