摘要
目的探讨急性ST段抬高型心肌梗死(STEMI)心肌灌注中采取血栓抽吸联合冠状动脉内注射重组人尿激酶原(rh-proUK)的疗效。方法以我院2018年5月至2020年5月收治的150例STEMI患者为研究对象,采用随机数字表法将患者分为研究1组(血栓抽吸联合冠状动脉内注射rh-proUK)与研究2组(血栓抽吸联合冠状动脉内注射盐酸替罗非班),每组75例,探讨实施不同治疗对TIMI分级、心功能及生活质量的影响。结果治疗前,研究对象的TIMI分级、心肌酶指标及生化质量评分等无明显差异(P>0.05)。治疗后,研究1组的TIMI分级显著高于研究2组(P<0.05)。术后2小时研究1组肌酸激酶同工酶(CK-MB)、肌钙蛋白I及左心室射血分数相较研究2组均显著改善(P<0.05),不良心脏事件发生率(1.33%vs.9.33%)、出血事件发生率(2.67%vs.12.00%)均显著低于研究2组(P<0.05)。结论采取血栓抽吸联合冠状动脉内注射rh-proUK可能有效地改善STEMI患者心功能与心肌灌注,其安全性和有效性需在大样本研究中进一步验证。
Objective To investigate the efficacy of thrombus aspiration combined with intracoronary injection of recombinant human urokininogen(RH proUK)in myocardial perfusion of acute ST segment elevation myocardial infarction(STEMI).Methods a total of 150 STEMI patients were divided into study 1(thrombus aspiration combined with intracoronary rh-proUK injection)and Study 2(thrombus aspiration combined with tirofiban hydrochloride injection)groups(75 patients each)by a random number table,and the subjects were admitted to our hospital from May 2018 to May 2020.5,in order to investigate the effect of implementing different treatments on TIMI grade,cardiac function and quality of life.Results There were no significant differences in the pre-treatment TIMI grade,cardiac enzyme indices and biochemical quality scores among the study subjects(all P>0.05),Post treatment study 1,compared to study 2,had higher TIMI grades(P<0.05),The peak creatine kinase isoenzyme(CK-MB)(132.07±12.14 vs.159.38±14.21,P<0.05)and peak serum levels of troponin I(CTN I)(5.45±0.57 vs.5.23±0.54,P<0.05),left ventricular ejection fraction(LVEF)(48.97±4.36 vs.47.02±4.20,P<0.05)was higher.The scores of study 1 were higher than those of study 2 after treatment(P<0.05),and in terms of the incidence of adverse cardiac events and bleeding events,they were 1.33%,2.67% in Study 1,9.33% and 12.00% in Study 2,respectively,with significant differences between the two groups(P<0.05).Conclusions The taking thrombus aspiration combined with intracoronary RH proUK injection may be effective in improving cardiac function and myocardial perfusion in STEMI patients,and its safety and efficacy need to be further verified in a large sample study.
作者
梁庆辉
陈太鸿
王石
耿爽
贺薏
梅立冬
齐艳鹏
陈宇
刘篪
LIANG Qing-hui;CHEN Tai-hong;WANG Shi;GENG Shuang;HE Yi;MEI Li-dong;QI Yan-peng;CHEN Yu;LIU Chi(Beidahuang Group Hongxinglong Hospital,Shuangyashan 155811,Heilongjiang,China)
出处
《中国分子心脏病学杂志》
CAS
2021年第4期4104-4107,共4页
Molecular Cardiology of China
基金
黑龙江省卫生健康委科研课题(2019-439)。
关键词
重组人尿激酶原
血栓抽吸
心肌灌注
急性ST段抬高型心肌梗死
Recombinant human urokinogen
Thrombus aspiration
Myocardial perfusion
Acute ST elevation myocardial infarction
